Development of a handheld diffuse optical breast cancer assessment probe
Diffuse Optical Spectroscopy (DOS) is a promising non-invasive and non-ionizing technique for breast anomaly detection. In this study, we have developed a new handheld DOS probe to measure optical properties of breast tissue. In the proposed probe, the breast tissue is illuminated with four near inf...
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| Format: | Article |
| Language: | English |
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World Scientific Publishing
2016-03-01
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| Series: | Journal of Innovative Optical Health Sciences |
| Subjects: | |
| Online Access: | http://www.worldscientific.com/doi/pdf/10.1142/S1793545816500073 |
| _version_ | 1811277766782353408 |
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| author | Majid Shokoufi Farid Golnaraghi |
| author_facet | Majid Shokoufi Farid Golnaraghi |
| author_sort | Majid Shokoufi |
| collection | DOAJ |
| description | Diffuse Optical Spectroscopy (DOS) is a promising non-invasive and non-ionizing technique for breast anomaly detection. In this study, we have developed a new handheld DOS probe to measure optical properties of breast tissue. In the proposed probe, the breast tissue is illuminated with four near infrared (NIR) wavelengths light emitting diodes (LED), which are encapsulated in a package (eLEDs), and two PIN photodiodes measure the intensity of the scattered photons at two different locations. The proposed technique of using eLEDs is introduced, in order to have a multi-wavelength pointed-beam illumination source instead of using the laser-coupled fiber-optic technique, which increases the complexity, size, and cost of the probe. Despite the fact that the proposed technique miniaturizes the probe and reduces the complexity of the DOS, the study proves that it is accurate and reliable in measuring optical properties of the tissue. The measurements are performed at the rate of 10Hz which is suitable for dynamic measurement of biological activity, in-vivo. The multi-spectral evaluation algorithm is used to reconstruct four main absorber concentrations in the breast including oxy-hemoglobin (cHb), deoxy-hemoglobin (cHbO2), water (cH2O), fat (cFat), and average scattering coefficient of the medium, as well as concentration changes in Hb (ΔcHb) and HbO2 (ΔcHbO2). Although the probe is designed for breast cancer diagnosis, it can be used in a wide range of applications for both static and dynamic measurements such as functional brain imaging. A series of phantoms, comprised of Delrin®, Intralipid®, PierceTM and Black ink, are used to verify performance of the device. The probe will be tested on human subjects, in-vivo, in the next phase. |
| first_indexed | 2024-04-13T00:22:44Z |
| format | Article |
| id | doaj.art-b7e36088d7df44cd8e2f731ee7b14948 |
| institution | Directory Open Access Journal |
| issn | 1793-5458 1793-7205 |
| language | English |
| last_indexed | 2024-04-13T00:22:44Z |
| publishDate | 2016-03-01 |
| publisher | World Scientific Publishing |
| record_format | Article |
| series | Journal of Innovative Optical Health Sciences |
| spelling | doaj.art-b7e36088d7df44cd8e2f731ee7b149482022-12-22T03:10:43ZengWorld Scientific PublishingJournal of Innovative Optical Health Sciences1793-54581793-72052016-03-01921650007-11650007-1010.1142/S179354581650007310.1142/S1793545816500073Development of a handheld diffuse optical breast cancer assessment probeMajid Shokoufi0Farid Golnaraghi1School of Mechatronic Systems Engineering, Simon Fraser University, 250-13450 102 Avenue, Surrey, Canada, BC V3T 0A3, CanadaSchool of Mechatronic Systems Engineering, Simon Fraser University, 250-13450 102 Avenue, Surrey, Canada, BC V3T 0A3, CanadaDiffuse Optical Spectroscopy (DOS) is a promising non-invasive and non-ionizing technique for breast anomaly detection. In this study, we have developed a new handheld DOS probe to measure optical properties of breast tissue. In the proposed probe, the breast tissue is illuminated with four near infrared (NIR) wavelengths light emitting diodes (LED), which are encapsulated in a package (eLEDs), and two PIN photodiodes measure the intensity of the scattered photons at two different locations. The proposed technique of using eLEDs is introduced, in order to have a multi-wavelength pointed-beam illumination source instead of using the laser-coupled fiber-optic technique, which increases the complexity, size, and cost of the probe. Despite the fact that the proposed technique miniaturizes the probe and reduces the complexity of the DOS, the study proves that it is accurate and reliable in measuring optical properties of the tissue. The measurements are performed at the rate of 10Hz which is suitable for dynamic measurement of biological activity, in-vivo. The multi-spectral evaluation algorithm is used to reconstruct four main absorber concentrations in the breast including oxy-hemoglobin (cHb), deoxy-hemoglobin (cHbO2), water (cH2O), fat (cFat), and average scattering coefficient of the medium, as well as concentration changes in Hb (ΔcHb) and HbO2 (ΔcHbO2). Although the probe is designed for breast cancer diagnosis, it can be used in a wide range of applications for both static and dynamic measurements such as functional brain imaging. A series of phantoms, comprised of Delrin®, Intralipid®, PierceTM and Black ink, are used to verify performance of the device. The probe will be tested on human subjects, in-vivo, in the next phase.http://www.worldscientific.com/doi/pdf/10.1142/S1793545816500073Breast cancerdiffuse optical spectroscopyintrinsic optical contrasthemoglobin concentrationoptical breast phantom |
| spellingShingle | Majid Shokoufi Farid Golnaraghi Development of a handheld diffuse optical breast cancer assessment probe Journal of Innovative Optical Health Sciences Breast cancer diffuse optical spectroscopy intrinsic optical contrast hemoglobin concentration optical breast phantom |
| title | Development of a handheld diffuse optical breast cancer assessment probe |
| title_full | Development of a handheld diffuse optical breast cancer assessment probe |
| title_fullStr | Development of a handheld diffuse optical breast cancer assessment probe |
| title_full_unstemmed | Development of a handheld diffuse optical breast cancer assessment probe |
| title_short | Development of a handheld diffuse optical breast cancer assessment probe |
| title_sort | development of a handheld diffuse optical breast cancer assessment probe |
| topic | Breast cancer diffuse optical spectroscopy intrinsic optical contrast hemoglobin concentration optical breast phantom |
| url | http://www.worldscientific.com/doi/pdf/10.1142/S1793545816500073 |
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