The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia.
BACKGROUND: Interleukin-15 (IL-15) plays important roles in the immune system and in the development of hematopoietic cells. Previous studies revealed that five SNPs in IL-15, rs10519612, rs10519613, rs35964658, rs17007695 and rs17015014, were significantly associated with childhood Acute Lymphoblas...
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2010-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC2963612?pdf=render |
| _version_ | 1819158199560830976 |
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| author | Dandan Lin Chunliang Liu Mengxing Xue Rengyun Liu Lan Jiang Xiao Yu Guangming Bao Fang Deng Mingjie Yu Jiafu Ao Yifeng Zhou Depei Wu Haiyan Liu |
| author_facet | Dandan Lin Chunliang Liu Mengxing Xue Rengyun Liu Lan Jiang Xiao Yu Guangming Bao Fang Deng Mingjie Yu Jiafu Ao Yifeng Zhou Depei Wu Haiyan Liu |
| author_sort | Dandan Lin |
| collection | DOAJ |
| description | BACKGROUND: Interleukin-15 (IL-15) plays important roles in the immune system and in the development of hematopoietic cells. Previous studies revealed that five SNPs in IL-15, rs10519612, rs10519613, rs35964658, rs17007695 and rs17015014, were significantly associated with childhood Acute Lymphoblastic Leukemia (ALL) treatment response. In adult ALL, the expression of IL-15 was also correlated with the immunophenotypes of ALL. Therefore, we hypothesize that SNPs of IL-15 might also be associated with adult ALL. METHODS AND FINDINGS: We genotyped the above five SNPs of IL-15 gene by PCR-RFLP assays in adult ALL case-control studies. The current study included 121 adult ALL patients and 263 healthy controls. IL-15 genotypes and haplotypes were determined and the associations with the risk of ALL were analyzed by logistic regression. SNPs rs10519612 and rs17007695 were significantly associated with ALL (P = 0.013 and P = 0.001). We observed a 2-fold and 2.4-fold excess risk of developing ALL for the rs10519612 CC and rs17007695 TC genotype carriers compared with non-carriers, respectively. Haplotype analysis revealed that haplotypes ACAC, CAGT and CCAT were significantly associated with adult B-ALL, while haplotype CCAT conferred susceptibility to T-ALL. CONCLUSION: These findings suggest that IL-15 gene polymorphisms are significantly associated with ALL in adult Chinese population. |
| first_indexed | 2024-12-22T16:20:52Z |
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| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-22T16:20:52Z |
| publishDate | 2010-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-b7e3bd8aa2d5470a91df0af4e30c69f12022-12-21T18:20:14ZengPublic Library of Science (PLoS)PLoS ONE1932-62032010-01-01510e1362610.1371/journal.pone.0013626The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia.Dandan LinChunliang LiuMengxing XueRengyun LiuLan JiangXiao YuGuangming BaoFang DengMingjie YuJiafu AoYifeng ZhouDepei WuHaiyan LiuBACKGROUND: Interleukin-15 (IL-15) plays important roles in the immune system and in the development of hematopoietic cells. Previous studies revealed that five SNPs in IL-15, rs10519612, rs10519613, rs35964658, rs17007695 and rs17015014, were significantly associated with childhood Acute Lymphoblastic Leukemia (ALL) treatment response. In adult ALL, the expression of IL-15 was also correlated with the immunophenotypes of ALL. Therefore, we hypothesize that SNPs of IL-15 might also be associated with adult ALL. METHODS AND FINDINGS: We genotyped the above five SNPs of IL-15 gene by PCR-RFLP assays in adult ALL case-control studies. The current study included 121 adult ALL patients and 263 healthy controls. IL-15 genotypes and haplotypes were determined and the associations with the risk of ALL were analyzed by logistic regression. SNPs rs10519612 and rs17007695 were significantly associated with ALL (P = 0.013 and P = 0.001). We observed a 2-fold and 2.4-fold excess risk of developing ALL for the rs10519612 CC and rs17007695 TC genotype carriers compared with non-carriers, respectively. Haplotype analysis revealed that haplotypes ACAC, CAGT and CCAT were significantly associated with adult B-ALL, while haplotype CCAT conferred susceptibility to T-ALL. CONCLUSION: These findings suggest that IL-15 gene polymorphisms are significantly associated with ALL in adult Chinese population.http://europepmc.org/articles/PMC2963612?pdf=render |
| spellingShingle | Dandan Lin Chunliang Liu Mengxing Xue Rengyun Liu Lan Jiang Xiao Yu Guangming Bao Fang Deng Mingjie Yu Jiafu Ao Yifeng Zhou Depei Wu Haiyan Liu The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. PLoS ONE |
| title | The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. |
| title_full | The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. |
| title_fullStr | The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. |
| title_full_unstemmed | The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. |
| title_short | The role of interleukin-15 polymorphisms in adult acute lymphoblastic leukemia. |
| title_sort | role of interleukin 15 polymorphisms in adult acute lymphoblastic leukemia |
| url | http://europepmc.org/articles/PMC2963612?pdf=render |
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