Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products
Cytokines and other growth factors are essential for cell expansion, health, function, and immune stimulation. Stem cells have the additional reliance on these factors to direct differentiation to the appropriate terminal cell type. Successful manufacturing of allogeneic cell therapies from induced...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-05-01
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| Series: | Biology |
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| Online Access: | https://www.mdpi.com/2079-7737/12/5/677 |
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| author | Chen-Yuan Kao Jason A. Mills Carl J. Burke Barry Morse Bruno F. Marques |
| author_facet | Chen-Yuan Kao Jason A. Mills Carl J. Burke Barry Morse Bruno F. Marques |
| author_sort | Chen-Yuan Kao |
| collection | DOAJ |
| description | Cytokines and other growth factors are essential for cell expansion, health, function, and immune stimulation. Stem cells have the additional reliance on these factors to direct differentiation to the appropriate terminal cell type. Successful manufacturing of allogeneic cell therapies from induced pluripotent stem cells (iPSCs) requires close attention to the selection and control of cytokines and factors used throughout the manufacturing process, as well as after administration to the patient. This paper employs iPSC-derived natural killer cell/T cell therapeutics to illustrate the use of cytokines, growth factors, and transcription factors at different stages of the manufacturing process, ranging from the generation of iPSCs to controlling of iPSC differentiation into immune-effector cells through the support of cell therapy after patient administration. |
| first_indexed | 2024-03-11T03:56:03Z |
| format | Article |
| id | doaj.art-b7e6ce75ae024d1392f6b26f7e1cf948 |
| institution | Directory Open Access Journal |
| issn | 2079-7737 |
| language | English |
| last_indexed | 2024-03-11T03:56:03Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biology |
| spelling | doaj.art-b7e6ce75ae024d1392f6b26f7e1cf9482023-11-18T00:32:51ZengMDPI AGBiology2079-77372023-05-0112567710.3390/biology12050677Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy ProductsChen-Yuan Kao0Jason A. Mills1Carl J. Burke2Barry Morse3Bruno F. Marques4Process and Product Development, Century Therapeutics, Philadelphia, PA 19104, USAProcess and Product Development, Century Therapeutics, Philadelphia, PA 19104, USAProcess and Product Development, Century Therapeutics, Philadelphia, PA 19104, USAResearch and Development, Century Therapeutics, Philadelphia, PA 19104, USAProcess and Product Development, Century Therapeutics, Philadelphia, PA 19104, USACytokines and other growth factors are essential for cell expansion, health, function, and immune stimulation. Stem cells have the additional reliance on these factors to direct differentiation to the appropriate terminal cell type. Successful manufacturing of allogeneic cell therapies from induced pluripotent stem cells (iPSCs) requires close attention to the selection and control of cytokines and factors used throughout the manufacturing process, as well as after administration to the patient. This paper employs iPSC-derived natural killer cell/T cell therapeutics to illustrate the use of cytokines, growth factors, and transcription factors at different stages of the manufacturing process, ranging from the generation of iPSCs to controlling of iPSC differentiation into immune-effector cells through the support of cell therapy after patient administration.https://www.mdpi.com/2079-7737/12/5/677cell therapyallogeneicpluripotentstem cellnatural killerT cell |
| spellingShingle | Chen-Yuan Kao Jason A. Mills Carl J. Burke Barry Morse Bruno F. Marques Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products Biology cell therapy allogeneic pluripotent stem cell natural killer T cell |
| title | Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products |
| title_full | Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products |
| title_fullStr | Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products |
| title_full_unstemmed | Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products |
| title_short | Role of Cytokines and Growth Factors in the Manufacturing of iPSC-Derived Allogeneic Cell Therapy Products |
| title_sort | role of cytokines and growth factors in the manufacturing of ipsc derived allogeneic cell therapy products |
| topic | cell therapy allogeneic pluripotent stem cell natural killer T cell |
| url | https://www.mdpi.com/2079-7737/12/5/677 |
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