The lipoprotein subfraction profile: heritability and identification of quantitative trait loci
The HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2) to...
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| Format: | Article |
| Language: | English |
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Elsevier
2008-04-01
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| Series: | Journal of Lipid Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520423855 |
| _version_ | 1818606116245864448 |
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| author | Bernhard Kaess Marcus Fischer Andrea Baessler Klaus Stark Fritz Huber Werner Kremer Hans Robert Kalbitzer Heribert Schunkert Guenter Riegger Christian Hengstenberg |
| author_facet | Bernhard Kaess Marcus Fischer Andrea Baessler Klaus Stark Fritz Huber Werner Kremer Hans Robert Kalbitzer Heribert Schunkert Guenter Riegger Christian Hengstenberg |
| author_sort | Bernhard Kaess |
| collection | DOAJ |
| description | The HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2) to identify gene loci influencing the lipoprotein subfraction pattern. Using NMR spectroscopy, we analyzed the lipoprotein subclass distribution in 1,275 coronary artery disease patients derived from the Regensburg Myocardial Infarction Family Study. We calculated heritabilities, performed a microsatellite genome scan, and calculated linkage. HDL and LDL subclass profiles showed heritabilities ranging from 23% to 67% (all P < 10−3) of traits using univariate calculation. After multivariate adjustment, we found heritabilities of 27–48% (all P < 0.05) for HDL and 21–44% for LDL traits. The linkage analysis revealed a significant logarithm of the odds (LOD) score (3.3) for HDL particle concentration on chromosome 18 and a highly suggestive signal for HDL particle size on chromosome 12 (2.9). After multivariate adjustment, we found a significant maximum LOD score of 3.7 for HDL size. Our study is the first to analyze heritability and linkage for the entire spectrum of LDL and HDL subclass features. Our findings may lead to the identification of genes controlling the lipoprotein subclass distribution. |
| first_indexed | 2024-12-16T14:05:44Z |
| format | Article |
| id | doaj.art-b7e75e31917e469181a376950cf60b0b |
| institution | Directory Open Access Journal |
| issn | 0022-2275 |
| language | English |
| last_indexed | 2024-12-16T14:05:44Z |
| publishDate | 2008-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Lipid Research |
| spelling | doaj.art-b7e75e31917e469181a376950cf60b0b2022-12-21T22:28:55ZengElsevierJournal of Lipid Research0022-22752008-04-01494715723The lipoprotein subfraction profile: heritability and identification of quantitative trait lociBernhard Kaess0Marcus Fischer1Andrea Baessler2Klaus Stark3Fritz Huber4Werner Kremer5Hans Robert Kalbitzer6Heribert Schunkert7Guenter Riegger8Christian Hengstenberg9Klinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, GermanyKlinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, GermanyKlinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, GermanyKlinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, GermanyInstitut für Biophysik und Physikalische Biochemie, University of Regensburg, and Lipofit GmbH, Regensburg, GermanyInstitut für Biophysik und Physikalische Biochemie, University of Regensburg, and Lipofit GmbH, Regensburg, GermanyInstitut für Biophysik und Physikalische Biochemie, University of Regensburg, and Lipofit GmbH, Regensburg, GermanyMedizinische Klinik II, University Hospital of Schleswig-Holstein, Lübeck, GermanyKlinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, GermanyKlinik und Poliklinik für Innere Medizin II, University of Regensburg, Regensburg, GermanyThe HDL and LDL subclass profile is an emerging cardiovascular risk factor. Yet, the biological and genetic mechanisms controlling the lipoprotein subclass distribution are unclear. Therefore, we aimed 1) to determine the heritability of the entire spectrum of LDL and HDL subclass features and 2) to identify gene loci influencing the lipoprotein subfraction pattern. Using NMR spectroscopy, we analyzed the lipoprotein subclass distribution in 1,275 coronary artery disease patients derived from the Regensburg Myocardial Infarction Family Study. We calculated heritabilities, performed a microsatellite genome scan, and calculated linkage. HDL and LDL subclass profiles showed heritabilities ranging from 23% to 67% (all P < 10−3) of traits using univariate calculation. After multivariate adjustment, we found heritabilities of 27–48% (all P < 0.05) for HDL and 21–44% for LDL traits. The linkage analysis revealed a significant logarithm of the odds (LOD) score (3.3) for HDL particle concentration on chromosome 18 and a highly suggestive signal for HDL particle size on chromosome 12 (2.9). After multivariate adjustment, we found a significant maximum LOD score of 3.7 for HDL size. Our study is the first to analyze heritability and linkage for the entire spectrum of LDL and HDL subclass features. Our findings may lead to the identification of genes controlling the lipoprotein subclass distribution.http://www.sciencedirect.com/science/article/pii/S0022227520423855linkage analysisHDLLDLsubclassesnmr spectroscopy |
| spellingShingle | Bernhard Kaess Marcus Fischer Andrea Baessler Klaus Stark Fritz Huber Werner Kremer Hans Robert Kalbitzer Heribert Schunkert Guenter Riegger Christian Hengstenberg The lipoprotein subfraction profile: heritability and identification of quantitative trait loci Journal of Lipid Research linkage analysis HDL LDL subclasses nmr spectroscopy |
| title | The lipoprotein subfraction profile: heritability and identification of quantitative trait loci |
| title_full | The lipoprotein subfraction profile: heritability and identification of quantitative trait loci |
| title_fullStr | The lipoprotein subfraction profile: heritability and identification of quantitative trait loci |
| title_full_unstemmed | The lipoprotein subfraction profile: heritability and identification of quantitative trait loci |
| title_short | The lipoprotein subfraction profile: heritability and identification of quantitative trait loci |
| title_sort | lipoprotein subfraction profile heritability and identification of quantitative trait loci |
| topic | linkage analysis HDL LDL subclasses nmr spectroscopy |
| url | http://www.sciencedirect.com/science/article/pii/S0022227520423855 |
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