Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus
Summary: Vorapaxar reduces thrombotic cardiovascular events at the expense of increased bleeding. However, the differential pharmacodynamic (PD) effects of vorapaxar according to diabetes mellitus (DM) status are unknown. Moreover, although withdrawal of aspirin has emerged as a bleeding reduction s...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
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| Series: | JACC: Basic to Translational Science |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2452302X19302256 |
| _version_ | 1818944309467021312 |
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| author | Francesco Franchi, MD Fabiana Rollini, MD Victor Kairouz, MD Jose Rivas Rios, MD Andrea Rivas, MD Malhar Agarwal, MD Maryuri Briceno, MD Mustafa Wali, MD Ahmed Nawaz, MD Gabriel Silva, MD Zubair Shaikh, MD Naji Maaliki, MD Latonya Been, AAS Jason Piraino, DPM Andres M. Pineda, MD Siva Suryadevara, MD Daniel Soffer, MD Martin M. Zenni, MD Lisa K. Jennings, PhD Theodore A. Bass, MD Dominick J. Angiolillo, MD, PhD |
| author_facet | Francesco Franchi, MD Fabiana Rollini, MD Victor Kairouz, MD Jose Rivas Rios, MD Andrea Rivas, MD Malhar Agarwal, MD Maryuri Briceno, MD Mustafa Wali, MD Ahmed Nawaz, MD Gabriel Silva, MD Zubair Shaikh, MD Naji Maaliki, MD Latonya Been, AAS Jason Piraino, DPM Andres M. Pineda, MD Siva Suryadevara, MD Daniel Soffer, MD Martin M. Zenni, MD Lisa K. Jennings, PhD Theodore A. Bass, MD Dominick J. Angiolillo, MD, PhD |
| author_sort | Francesco Franchi, MD |
| collection | DOAJ |
| description | Summary: Vorapaxar reduces thrombotic cardiovascular events at the expense of increased bleeding. However, the differential pharmacodynamic (PD) effects of vorapaxar according to diabetes mellitus (DM) status are unknown. Moreover, although withdrawal of aspirin has emerged as a bleeding reduction strategy, the PD effects of stopping aspirin in patients treated with vorapaxar also are unknown. In this prospective PD investigation, vorapaxar was associated with reduced platelet-mediated thrombogenicity without affecting clot kinetics irrespective of DM status. However, platelet-mediated thrombogenicity increased after aspirin withdrawal, particularly among patients with DM. (Optimizing anti-Platelet Therapy In diabetes MellitUS-5 Study [OPTIMUS-5]; NCT02548650) Key Words: dual antiplatelet therapy, pharmacodynamics, platelets, thrombin, vorapaxar |
| first_indexed | 2024-12-20T07:41:10Z |
| format | Article |
| id | doaj.art-b7ea15f9ac70419180a5ce0ec8e4c853 |
| institution | Directory Open Access Journal |
| issn | 2452-302X |
| language | English |
| last_indexed | 2024-12-20T07:41:10Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | JACC: Basic to Translational Science |
| spelling | doaj.art-b7ea15f9ac70419180a5ce0ec8e4c8532022-12-21T19:48:08ZengElsevierJACC: Basic to Translational Science2452-302X2019-11-0147763775Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes MellitusFrancesco Franchi, MD0Fabiana Rollini, MD1Victor Kairouz, MD2Jose Rivas Rios, MD3Andrea Rivas, MD4Malhar Agarwal, MD5Maryuri Briceno, MD6Mustafa Wali, MD7Ahmed Nawaz, MD8Gabriel Silva, MD9Zubair Shaikh, MD10Naji Maaliki, MD11Latonya Been, AAS12Jason Piraino, DPM13Andres M. Pineda, MD14Siva Suryadevara, MD15Daniel Soffer, MD16Martin M. Zenni, MD17Lisa K. Jennings, PhD18Theodore A. Bass, MD19Dominick J. Angiolillo, MD, PhD20Division of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Foot and Ankle, Department of Orthopaedic Surgery and Rehabilitation, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaCirQuest Labs, Memphis, TennesseeDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, FloridaDivision of Cardiology, Department of Medicine, University of Florida College of Medicine–Jacksonville, Jacksonville, Florida; Address for correspondence: Dr. Dominick J. Angiolillo, University of Florida College of Medicine–Jacksonville, 655 West 8th Street, Jacksonville, Florida 32209.Summary: Vorapaxar reduces thrombotic cardiovascular events at the expense of increased bleeding. However, the differential pharmacodynamic (PD) effects of vorapaxar according to diabetes mellitus (DM) status are unknown. Moreover, although withdrawal of aspirin has emerged as a bleeding reduction strategy, the PD effects of stopping aspirin in patients treated with vorapaxar also are unknown. In this prospective PD investigation, vorapaxar was associated with reduced platelet-mediated thrombogenicity without affecting clot kinetics irrespective of DM status. However, platelet-mediated thrombogenicity increased after aspirin withdrawal, particularly among patients with DM. (Optimizing anti-Platelet Therapy In diabetes MellitUS-5 Study [OPTIMUS-5]; NCT02548650) Key Words: dual antiplatelet therapy, pharmacodynamics, platelets, thrombin, vorapaxarhttp://www.sciencedirect.com/science/article/pii/S2452302X19302256 |
| spellingShingle | Francesco Franchi, MD Fabiana Rollini, MD Victor Kairouz, MD Jose Rivas Rios, MD Andrea Rivas, MD Malhar Agarwal, MD Maryuri Briceno, MD Mustafa Wali, MD Ahmed Nawaz, MD Gabriel Silva, MD Zubair Shaikh, MD Naji Maaliki, MD Latonya Been, AAS Jason Piraino, DPM Andres M. Pineda, MD Siva Suryadevara, MD Daniel Soffer, MD Martin M. Zenni, MD Lisa K. Jennings, PhD Theodore A. Bass, MD Dominick J. Angiolillo, MD, PhD Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus JACC: Basic to Translational Science |
| title | Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus |
| title_full | Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus |
| title_fullStr | Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus |
| title_full_unstemmed | Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus |
| title_short | Pharmacodynamic Effects of Vorapaxar in Patients With and Without Diabetes Mellitus |
| title_sort | pharmacodynamic effects of vorapaxar in patients with and without diabetes mellitus |
| url | http://www.sciencedirect.com/science/article/pii/S2452302X19302256 |
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