Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

Activity-dependent tau cleavage by caspase-3 promotes neuronal dysfunction and synaptotoxicity

Summary: Tau-mediated toxicity is associated with cognitive decline and Alzheimer’s disease (AD) progression. In particular, tau post-translational modifications (PTMs) are thought to generate aberrant tau species resulting in neuronal dysfunction. Despite being well characterized in postmortem AD b...

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Bibliographic Details
Main Authors: Carli K. Opland, Miles R. Bryan, Braxton Harris, Jake McGillion-Moore, Xu Tian, Youjun Chen, Michelle S. Itano, Graham H. Diering, Rick B. Meeker, Todd J. Cohen
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:iScience
Subjects:
Molecular neuroscience
Cellular neuroscience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004223009823

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