The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction
Abstract The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growt...
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Nature Portfolio
2017-08-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-017-09564-9 |
| _version_ | 1818750791531364352 |
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| author | Agata Bielecka-Dabrowa Agata Sakowicz Tadeusz Pietrucha Małgorzata Misztal Piotr Chruściel Jacek Rysz Maciej Banach |
| author_facet | Agata Bielecka-Dabrowa Agata Sakowicz Tadeusz Pietrucha Małgorzata Misztal Piotr Chruściel Jacek Rysz Maciej Banach |
| author_sort | Agata Bielecka-Dabrowa |
| collection | DOAJ |
| description | Abstract The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A].110 patients with HF with preserved and mid-range ejection fraction (HFpEF and HFmrEF) were recruited. GG homozygotes in 174 G/C of IL6 polymorphism are characterized by higher values of estimated glomerular filtration rate based on the study Modification of Diet in Renal Disease (eGFR MDRD) and C allele in the NOS polymorphism and AA profile in C-1260A of CYP27B1 polymorphism correlated with a lower eGFR (MDRD). In multivariate analysis the CG genotype for 174 G/C of IL-6 and allele A in C-1260A of CYP27B1 are the only SNPs independently associated with worse course of HFpEF and HFmrEF. These data confirm the importance of the selected SNPs in aggravation and complications of hypertension. |
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| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-12-18T04:25:17Z |
| publishDate | 2017-08-01 |
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| series | Scientific Reports |
| spelling | doaj.art-b7f17e42c1f24049821f3a6eabad25022022-12-21T21:21:07ZengNature PortfolioScientific Reports2045-23222017-08-017111210.1038/s41598-017-09564-9The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fractionAgata Bielecka-Dabrowa0Agata Sakowicz1Tadeusz Pietrucha2Małgorzata Misztal3Piotr Chruściel4Jacek Rysz5Maciej Banach6Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9Department of Medical Biotechnology, Medical University of Lodz, Zeligowskiego 7/9Chair of Statistical Methods, Faculty of Economics and Sociology, University of Lodz; Rewolucji 1905/41Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113Department of Nephrology, Hypertension and Family Medicine, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113Department of Hypertension, Chair of Nephrology and Hypertension, Medical University of Lodz, Zeromskiego 113Abstract The study aimed to assess the clinical significance of selected single nucleotide polymorphisms (SNPs) in patients with diastolic heart failure (HF): inflammation [-174 G/C Interleukin -6 (IL-6) rs1800795, tumor necrosis factor (TNF)-608 G/A rs1800629], fibrosis [Arg25Pro transforming growth factor β (TGF β) rs1800471], endothelial function [-786 T/C nitric oxide synthase (NOS) rs2070744], glucose and lipid metabolism [Pro12Ala peroxisome proliferator activated receptor (PPAR)γ rs1801282], and vitamin D metabolism [cytochrome P450 27B1 (CYP27B1) C-1260A].110 patients with HF with preserved and mid-range ejection fraction (HFpEF and HFmrEF) were recruited. GG homozygotes in 174 G/C of IL6 polymorphism are characterized by higher values of estimated glomerular filtration rate based on the study Modification of Diet in Renal Disease (eGFR MDRD) and C allele in the NOS polymorphism and AA profile in C-1260A of CYP27B1 polymorphism correlated with a lower eGFR (MDRD). In multivariate analysis the CG genotype for 174 G/C of IL-6 and allele A in C-1260A of CYP27B1 are the only SNPs independently associated with worse course of HFpEF and HFmrEF. These data confirm the importance of the selected SNPs in aggravation and complications of hypertension.https://doi.org/10.1038/s41598-017-09564-9 |
| spellingShingle | Agata Bielecka-Dabrowa Agata Sakowicz Tadeusz Pietrucha Małgorzata Misztal Piotr Chruściel Jacek Rysz Maciej Banach The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction Scientific Reports |
| title | The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction |
| title_full | The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction |
| title_fullStr | The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction |
| title_full_unstemmed | The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction |
| title_short | The profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid-range ejection fraction |
| title_sort | profile of selected single nucleotide polymorphisms in patients with hypertension and heart failure with preserved and mid range ejection fraction |
| url | https://doi.org/10.1038/s41598-017-09564-9 |
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