Amiloidose primária associado a mieloma de cadeias leves kappa.
The clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases.A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed norma...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Ordem dos Médicos
2010-04-01
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| Series: | Acta Médica Portuguesa |
| Online Access: | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/603 |
| _version_ | 1817980201083076608 |
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| author | Raquel G Martins Roberto Roncon-Albuquerque Raquel Cabral João Frazão Pedro Von Hafe |
| author_facet | Raquel G Martins Roberto Roncon-Albuquerque Raquel Cabral João Frazão Pedro Von Hafe |
| author_sort | Raquel G Martins |
| collection | DOAJ |
| description | The clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases.A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils in abdominal subcutaneous fat was positive. The serum beta-2 microglobulin level was elevated (26 mg/L). Transthoracic echocardiogram did not reveal pathologic findings. Treatment initiation was complicated by hemodialysis catheter-associated Staphylococcus aureus infection.Primary amyloidosis associated with light chain myeloma is a rare, and often late, diagnosis with a dismal prognosis. Renal failure is a frequent initial presentation of the disease and infection an important cause of death. |
| first_indexed | 2024-04-13T22:51:28Z |
| format | Article |
| id | doaj.art-b7f44f37757e49eeae454cef76a037e6 |
| institution | Directory Open Access Journal |
| issn | 0870-399X 1646-0758 |
| language | English |
| last_indexed | 2024-04-13T22:51:28Z |
| publishDate | 2010-04-01 |
| publisher | Ordem dos Médicos |
| record_format | Article |
| series | Acta Médica Portuguesa |
| spelling | doaj.art-b7f44f37757e49eeae454cef76a037e62022-12-22T02:26:11ZengOrdem dos MédicosActa Médica Portuguesa0870-399X1646-07582010-04-0123210.20344/amp.603Amiloidose primária associado a mieloma de cadeias leves kappa.Raquel G Martins0Roberto Roncon-AlbuquerqueRaquel CabralJoão FrazãoPedro Von HafeServiço de Endocrinologia, Instituto Português de Oncologia do Porto, Porto.The clinical spectrum of plasma cell dyscrasias includes primary amyloidosis and multiple myeloma. These two entities are present at the time of diagnosis in 10 percent of cases.A 72 years old female was admitted to our Institution with oligoanuric renal failure. Renal ultrasonography revealed normal kidney dimensions, with a slight decrease in the normal parenchyma-sinus differentiation. The complementary study identified free kappa light chains in urine (73,9 mg/dL) and bone marrow study fulfilled the criteria for multiple myeloma. Search for amyloid fibrils in abdominal subcutaneous fat was positive. The serum beta-2 microglobulin level was elevated (26 mg/L). Transthoracic echocardiogram did not reveal pathologic findings. Treatment initiation was complicated by hemodialysis catheter-associated Staphylococcus aureus infection.Primary amyloidosis associated with light chain myeloma is a rare, and often late, diagnosis with a dismal prognosis. Renal failure is a frequent initial presentation of the disease and infection an important cause of death.https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/603 |
| spellingShingle | Raquel G Martins Roberto Roncon-Albuquerque Raquel Cabral João Frazão Pedro Von Hafe Amiloidose primária associado a mieloma de cadeias leves kappa. Acta Médica Portuguesa |
| title | Amiloidose primária associado a mieloma de cadeias leves kappa. |
| title_full | Amiloidose primária associado a mieloma de cadeias leves kappa. |
| title_fullStr | Amiloidose primária associado a mieloma de cadeias leves kappa. |
| title_full_unstemmed | Amiloidose primária associado a mieloma de cadeias leves kappa. |
| title_short | Amiloidose primária associado a mieloma de cadeias leves kappa. |
| title_sort | amiloidose primaria associado a mieloma de cadeias leves kappa |
| url | https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/603 |
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