Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling
The molecular mechanisms through which pulmonary endothelial progenitor cells stimulate lung angiogenesis are not clear. Here, authors show that these cells stimulate the growth of alveolar capillaries and alveoli of newborn mice through FOXF1 and FLI1 nuclear protein-activation of the BMP9/ACVRL1/S...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-29746-y |
| _version_ | 1817988803020718080 |
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| author | Guolun Wang Bingqiang Wen Zicheng Deng Yufang Zhang Olena A. Kolesnichenko Vladimir Ustiyan Arun Pradhan Tanya V. Kalin Vladimir V. Kalinichenko |
| author_facet | Guolun Wang Bingqiang Wen Zicheng Deng Yufang Zhang Olena A. Kolesnichenko Vladimir Ustiyan Arun Pradhan Tanya V. Kalin Vladimir V. Kalinichenko |
| author_sort | Guolun Wang |
| collection | DOAJ |
| description | The molecular mechanisms through which pulmonary endothelial progenitor cells stimulate lung angiogenesis are not clear. Here, authors show that these cells stimulate the growth of alveolar capillaries and alveoli of newborn mice through FOXF1 and FLI1 nuclear protein-activation of the BMP9/ACVRL1/SMAD1 signaling pathway. |
| first_indexed | 2024-04-14T00:38:59Z |
| format | Article |
| id | doaj.art-b7f60e62031248e3bc0643614f405a31 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-14T00:38:59Z |
| publishDate | 2022-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b7f60e62031248e3bc0643614f405a312022-12-22T02:22:16ZengNature PortfolioNature Communications2041-17232022-04-0113111610.1038/s41467-022-29746-yEndothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signalingGuolun Wang0Bingqiang Wen1Zicheng Deng2Yufang Zhang3Olena A. Kolesnichenko4Vladimir Ustiyan5Arun Pradhan6Tanya V. Kalin7Vladimir V. Kalinichenko8Center for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterDivision of Pulmonary Biology, Cincinnati Children’s Hospital Medical CenterCenter for Lung Regenerative Medicine, Perinatal Institute, Cincinnati Children’s Hospital Medical CenterThe molecular mechanisms through which pulmonary endothelial progenitor cells stimulate lung angiogenesis are not clear. Here, authors show that these cells stimulate the growth of alveolar capillaries and alveoli of newborn mice through FOXF1 and FLI1 nuclear protein-activation of the BMP9/ACVRL1/SMAD1 signaling pathway.https://doi.org/10.1038/s41467-022-29746-y |
| spellingShingle | Guolun Wang Bingqiang Wen Zicheng Deng Yufang Zhang Olena A. Kolesnichenko Vladimir Ustiyan Arun Pradhan Tanya V. Kalin Vladimir V. Kalinichenko Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling Nature Communications |
| title | Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling |
| title_full | Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling |
| title_fullStr | Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling |
| title_full_unstemmed | Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling |
| title_short | Endothelial progenitor cells stimulate neonatal lung angiogenesis through FOXF1-mediated activation of BMP9/ACVRL1 signaling |
| title_sort | endothelial progenitor cells stimulate neonatal lung angiogenesis through foxf1 mediated activation of bmp9 acvrl1 signaling |
| url | https://doi.org/10.1038/s41467-022-29746-y |
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