A Critical Review of Kaempferol in Intestinal Health and Diseases
Kaempferol, a secondary metabolite found in plants, is a naturally occurring flavonoid displaying significant potential in various biological activities. The chemical structure of kaempferol is distinguished by the presence of phenyl rings and four hydroxyl substituents, which make it an exceptional...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-08-01
|
| Series: | Antioxidants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-3921/12/8/1642 |
| _version_ | 1797585705317171200 |
|---|---|
| author | Jun Chen Haopeng Zhong Zhouyin Huang Xingping Chen Jinming You Tiande Zou |
| author_facet | Jun Chen Haopeng Zhong Zhouyin Huang Xingping Chen Jinming You Tiande Zou |
| author_sort | Jun Chen |
| collection | DOAJ |
| description | Kaempferol, a secondary metabolite found in plants, is a naturally occurring flavonoid displaying significant potential in various biological activities. The chemical structure of kaempferol is distinguished by the presence of phenyl rings and four hydroxyl substituents, which make it an exceptional radical scavenger. Most recently, an increasing number of studies have demonstrated the significance of kaempferol in the regulation of intestinal function and the mitigation of intestinal inflammation. The focus of the review will primarily be on its impact in terms of antioxidant properties, inflammation, maintenance of intestinal barrier function, and its potential in the treatment of colorectal cancer and obesity. Future research endeavors should additionally give priority to investigating the specific dosage and duration of kaempferol administration for different pathological conditions, while simultaneously conducting deeper investigations into the comprehensible mechanisms of action related to the regulation of aryl hydrocarbon receptor (AhR). This review intends to present novel evidence supporting the utilization of kaempferol in the regulation of gut health and the management of associated diseases. |
| first_indexed | 2024-03-11T00:10:51Z |
| format | Article |
| id | doaj.art-b7f6d37c2999451b8099a17f01e28cd4 |
| institution | Directory Open Access Journal |
| issn | 2076-3921 |
| language | English |
| last_indexed | 2024-03-11T00:10:51Z |
| publishDate | 2023-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antioxidants |
| spelling | doaj.art-b7f6d37c2999451b8099a17f01e28cd42023-11-19T00:03:11ZengMDPI AGAntioxidants2076-39212023-08-01128164210.3390/antiox12081642A Critical Review of Kaempferol in Intestinal Health and DiseasesJun Chen0Haopeng Zhong1Zhouyin Huang2Xingping Chen3Jinming You4Tiande Zou5Jiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, ChinaJiangxi Province Key Laboratory of Animal Nutrition, College of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, ChinaKaempferol, a secondary metabolite found in plants, is a naturally occurring flavonoid displaying significant potential in various biological activities. The chemical structure of kaempferol is distinguished by the presence of phenyl rings and four hydroxyl substituents, which make it an exceptional radical scavenger. Most recently, an increasing number of studies have demonstrated the significance of kaempferol in the regulation of intestinal function and the mitigation of intestinal inflammation. The focus of the review will primarily be on its impact in terms of antioxidant properties, inflammation, maintenance of intestinal barrier function, and its potential in the treatment of colorectal cancer and obesity. Future research endeavors should additionally give priority to investigating the specific dosage and duration of kaempferol administration for different pathological conditions, while simultaneously conducting deeper investigations into the comprehensible mechanisms of action related to the regulation of aryl hydrocarbon receptor (AhR). This review intends to present novel evidence supporting the utilization of kaempferol in the regulation of gut health and the management of associated diseases.https://www.mdpi.com/2076-3921/12/8/1642antioxidantintestinal barrier functionintestinal healthintestinal inflammationkaempferol |
| spellingShingle | Jun Chen Haopeng Zhong Zhouyin Huang Xingping Chen Jinming You Tiande Zou A Critical Review of Kaempferol in Intestinal Health and Diseases Antioxidants antioxidant intestinal barrier function intestinal health intestinal inflammation kaempferol |
| title | A Critical Review of Kaempferol in Intestinal Health and Diseases |
| title_full | A Critical Review of Kaempferol in Intestinal Health and Diseases |
| title_fullStr | A Critical Review of Kaempferol in Intestinal Health and Diseases |
| title_full_unstemmed | A Critical Review of Kaempferol in Intestinal Health and Diseases |
| title_short | A Critical Review of Kaempferol in Intestinal Health and Diseases |
| title_sort | critical review of kaempferol in intestinal health and diseases |
| topic | antioxidant intestinal barrier function intestinal health intestinal inflammation kaempferol |
| url | https://www.mdpi.com/2076-3921/12/8/1642 |
| work_keys_str_mv | AT junchen acriticalreviewofkaempferolinintestinalhealthanddiseases AT haopengzhong acriticalreviewofkaempferolinintestinalhealthanddiseases AT zhouyinhuang acriticalreviewofkaempferolinintestinalhealthanddiseases AT xingpingchen acriticalreviewofkaempferolinintestinalhealthanddiseases AT jinmingyou acriticalreviewofkaempferolinintestinalhealthanddiseases AT tiandezou acriticalreviewofkaempferolinintestinalhealthanddiseases AT junchen criticalreviewofkaempferolinintestinalhealthanddiseases AT haopengzhong criticalreviewofkaempferolinintestinalhealthanddiseases AT zhouyinhuang criticalreviewofkaempferolinintestinalhealthanddiseases AT xingpingchen criticalreviewofkaempferolinintestinalhealthanddiseases AT jinmingyou criticalreviewofkaempferolinintestinalhealthanddiseases AT tiandezou criticalreviewofkaempferolinintestinalhealthanddiseases |