Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) is still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity against tumor cells. Here, we exploi...

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Bibliographic Details
Main Authors: Wei Tian, Zhuo Wang, Nan-nan Tang, Jia-tong Li, Yu Liu, Wen-Feng Chu, Bao-Feng Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-02-01
Series:Frontiers in Pharmacology
Subjects:
colorectal cancer
ascorbic acid
arsenic trioxide
apoptosis
pyroptosis
reactive oxygen species
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2020.00123/full

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