Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients
Background and objectiveMixed bacterial infections (MBI) is one of the complications after hematopoietic stem cell transplantation (HSCT) and increases the risk of patient death. However, there are few reports specifically on this topic. The purpose of this study was to investigate the clinical char...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-09-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1223824/full |
| _version_ | 1797681950463361024 |
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| author | Yanfeng Liu Yanfeng Liu Yanfeng Liu Yi Liu Yi Liu Xuefeng Chen Yan Jia Yan Jia |
| author_facet | Yanfeng Liu Yanfeng Liu Yanfeng Liu Yi Liu Yi Liu Xuefeng Chen Yan Jia Yan Jia |
| author_sort | Yanfeng Liu |
| collection | DOAJ |
| description | Background and objectiveMixed bacterial infections (MBI) is one of the complications after hematopoietic stem cell transplantation (HSCT) and increases the risk of patient death. However, there are few reports specifically on this topic. The purpose of this study was to investigate the clinical characteristics and mortality risk factors of MBI in HSCT recipients.MethodsThe electronic medical records of patients undergoing HSCT were collected. The epidemiological features and antibiotic resistance of patients with and without MBI were compared. Logistic regression and Cox regression were used to identify the risk factors for MBI acquisition and death. R language was used to construct a prediction model for the overall survival of HSCT recipients with MBI.ResultsThe cumulative incidence of MBI was 6.3% and the mortality was 48.8%. Time interval from diagnosis to transplantation > 180 days (HR=2.059, 95% CI 1.042-4.069, P=0.038) and ICU admission after transplantation (HR=2.271, 95% CI 1.053-4.898, P=0.036) were independent risk factors for MBI acquisition. Engraftment period > 20 days (HR=2.273, 95% CI 1.028-5.027, P=0.043), continuous renal replacement therapy (HR=5.755, 95% CI 1.691-19.589, P=0.005) and septic shock (HR=4.308, 95% CI 2.085-8.901, P=0.000) were independent risk factors associated with mortality.ConclusionsMBI has become a serious problem that cannot be ignored after HSCT. It is urgent for clinicians to pay high attention to it and formulate reasonable monitoring and treatment plans to improve the prognosis of patients. |
| first_indexed | 2024-03-11T23:52:27Z |
| format | Article |
| id | doaj.art-b7f9185e27224359afc40db5ed616171 |
| institution | Directory Open Access Journal |
| issn | 2235-2988 |
| language | English |
| last_indexed | 2024-03-11T23:52:27Z |
| publishDate | 2023-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj.art-b7f9185e27224359afc40db5ed6161712023-09-19T06:20:41ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882023-09-011310.3389/fcimb.2023.12238241223824Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipientsYanfeng Liu0Yanfeng Liu1Yanfeng Liu2Yi Liu3Yi Liu4Xuefeng Chen5Yan Jia6Yan Jia7Department of Hematology, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaDepartment of Hematology, The Third Xiangya Hospital of Central South University, Changsha, ChinaDepartment of Hematology, Xiangya Hospital, Central South University, Changsha, ChinaNational Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, ChinaBackground and objectiveMixed bacterial infections (MBI) is one of the complications after hematopoietic stem cell transplantation (HSCT) and increases the risk of patient death. However, there are few reports specifically on this topic. The purpose of this study was to investigate the clinical characteristics and mortality risk factors of MBI in HSCT recipients.MethodsThe electronic medical records of patients undergoing HSCT were collected. The epidemiological features and antibiotic resistance of patients with and without MBI were compared. Logistic regression and Cox regression were used to identify the risk factors for MBI acquisition and death. R language was used to construct a prediction model for the overall survival of HSCT recipients with MBI.ResultsThe cumulative incidence of MBI was 6.3% and the mortality was 48.8%. Time interval from diagnosis to transplantation > 180 days (HR=2.059, 95% CI 1.042-4.069, P=0.038) and ICU admission after transplantation (HR=2.271, 95% CI 1.053-4.898, P=0.036) were independent risk factors for MBI acquisition. Engraftment period > 20 days (HR=2.273, 95% CI 1.028-5.027, P=0.043), continuous renal replacement therapy (HR=5.755, 95% CI 1.691-19.589, P=0.005) and septic shock (HR=4.308, 95% CI 2.085-8.901, P=0.000) were independent risk factors associated with mortality.ConclusionsMBI has become a serious problem that cannot be ignored after HSCT. It is urgent for clinicians to pay high attention to it and formulate reasonable monitoring and treatment plans to improve the prognosis of patients.https://www.frontiersin.org/articles/10.3389/fcimb.2023.1223824/fullmixed bacterial infectionshematopoietic stem cell transplantationdrug resistancemortalityrisk factors |
| spellingShingle | Yanfeng Liu Yanfeng Liu Yanfeng Liu Yi Liu Yi Liu Xuefeng Chen Yan Jia Yan Jia Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients Frontiers in Cellular and Infection Microbiology mixed bacterial infections hematopoietic stem cell transplantation drug resistance mortality risk factors |
| title | Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients |
| title_full | Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients |
| title_fullStr | Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients |
| title_full_unstemmed | Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients |
| title_short | Clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients |
| title_sort | clinical characteristics and mortality risk factors of mixed bacterial infections in hematopoietic stem cell transplantation recipients |
| topic | mixed bacterial infections hematopoietic stem cell transplantation drug resistance mortality risk factors |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2023.1223824/full |
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