Synthesis of (<i>S</i>)- and (<i>R</i>)-β-Tyrosine by Redesigned Phenylalanine Aminomutase

Synthesis of (<i>S</i>)- and (<i>R</i>)-β-Tyrosine by Redesigned Phenylalanine Aminomutase

Phenylalanine aminomutase from <i>Taxus chinensis</i> (TchPAM) is employed in the biosynthesis of the widely used antitumor drug paclitaxel. TchPAM has received substantial attention due to its strict enantioselectivity towards (<i>R</i>)-β-phenylalanine, in contrast to the b...

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Bibliographic Details
Main Authors: Fei Peng, Habibu Aliyu, André Delavault, Ulrike Engel, Jens Rudat
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Catalysts
Subjects:
enantioselectivity
β-amino acid
computational enzyme design
functional residues TchPAM
phenylalanine aminomutase
Online Access:https://www.mdpi.com/2073-4344/12/4/397

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