Autoantibodies against BAFF, APRIL or IL21 - an alternative pathogenesis for antibody-deficiencies?

Autoantibodies against BAFF, APRIL or IL21 - an alternative pathogenesis for antibody-deficiencies?

Abstract Background The ability of anti-cytokine antibodies to play a disease-causing role in the pathogenesis of immunodeficiencies is widely accepted. The aim of this study was to investigate whether autoantibodies against BAFF (important B cell survival signal), APRIL (important plasma cell survi...

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Bibliographic Details
Main Authors: Marian-Christopher Pott, Natalie Frede, Jennifer Wanders, Lennart Hammarström, Erik-Oliver Glocker, Cristina Glocker, Fariba Tahami, Bodo Grimbacher
Format: Article
Language:English
Published: BMC 2017-06-01
Series:BMC Immunology
Subjects:
Autoimmunity
Autoantibodies
Cytokines
Primary antibody deficiency
Common variable immunodeficiency
Selective IgA deficiency
Online Access:http://link.springer.com/article/10.1186/s12865-017-0217-9

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