Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats
Background: The unprecedented increase in metal exposure has been aided by modern industrialization and anthropogenic activities. Cadmium and mercury are recognized as two of the most common heavy metals with destructive impacts on most organ systems. The present study was designed to investigate a...
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| Format: | Article |
| Language: | English |
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Nigerian Medical Association, Akwa Ibom State Branch
2022-05-01
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| Series: | Ibom Medical Journal |
| Subjects: | |
| Online Access: | https://ibommedicaljournal.org/index.php/imjhome/article/view/252 |
| _version_ | 1797271899262156800 |
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| author | Enogieru AB Inneh CA |
| author_facet | Enogieru AB Inneh CA |
| author_sort | Enogieru AB |
| collection | DOAJ |
| description |
Background: The unprecedented increase in metal exposure has been aided by modern industrialization and anthropogenic activities. Cadmium and mercury are recognized as two of the most common heavy metals with destructive impacts on most organ systems. The present study was designed to investigate and improve existing literature on the possible deleterious effects of cadmium and mercury exposure.
Methods: Adult Wistar rats were treated with cadmium chloride (5 mg/kg/day) and mercury chloride (4 mg/kg/day) for 14 days. Body, brain and cerebellar weights, motor deficits, antioxidant and lipid peroxidation activities as well as histological alterations to the cerebellum were evaluated at the end of the experiment.
Results: Findings showed a significant reduction in body and brain weights, dysregulation of antioxidant enzymes activity and impaired locomotion and exploratory activity in treated rats. Also, an increase in lipid peroxidation and degeneration of Purkinje cells of the cerebellum was observed in treated rats.
Conclusion: Overall, these results corroborate previous findings that cadmium and mercury induce deleterious effects on the cerebellum and central nervous system. In addition, this study helps to provide an anatomical perspective and information on the exact cerebellar changes induced by cadmium and mercury in Wistar rats.
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| first_indexed | 2024-03-07T14:16:48Z |
| format | Article |
| id | doaj.art-b7fb5c27ef0c4f3cad1f6ba234ea6816 |
| institution | Directory Open Access Journal |
| issn | 1597-7188 2735-9964 |
| language | English |
| last_indexed | 2024-03-07T14:16:48Z |
| publishDate | 2022-05-01 |
| publisher | Nigerian Medical Association, Akwa Ibom State Branch |
| record_format | Article |
| series | Ibom Medical Journal |
| spelling | doaj.art-b7fb5c27ef0c4f3cad1f6ba234ea68162024-03-06T12:02:58ZengNigerian Medical Association, Akwa Ibom State BranchIbom Medical Journal1597-71882735-99642022-05-0115210.61386/imj.v15i2.252Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar RatsEnogieru AB0Inneh CA1Department of Anatomy, School of Basic Medical Sciences, University of Benin, Edo State, Nigeria.Department of Physiology, School of Basic Medical Sciences, University of Benin, Edo State, Nigeria Background: The unprecedented increase in metal exposure has been aided by modern industrialization and anthropogenic activities. Cadmium and mercury are recognized as two of the most common heavy metals with destructive impacts on most organ systems. The present study was designed to investigate and improve existing literature on the possible deleterious effects of cadmium and mercury exposure. Methods: Adult Wistar rats were treated with cadmium chloride (5 mg/kg/day) and mercury chloride (4 mg/kg/day) for 14 days. Body, brain and cerebellar weights, motor deficits, antioxidant and lipid peroxidation activities as well as histological alterations to the cerebellum were evaluated at the end of the experiment. Results: Findings showed a significant reduction in body and brain weights, dysregulation of antioxidant enzymes activity and impaired locomotion and exploratory activity in treated rats. Also, an increase in lipid peroxidation and degeneration of Purkinje cells of the cerebellum was observed in treated rats. Conclusion: Overall, these results corroborate previous findings that cadmium and mercury induce deleterious effects on the cerebellum and central nervous system. In addition, this study helps to provide an anatomical perspective and information on the exact cerebellar changes induced by cadmium and mercury in Wistar rats. https://ibommedicaljournal.org/index.php/imjhome/article/view/252NeurotoxicityCadmiumMercuryLocomotionExplorationCerebellum |
| spellingShingle | Enogieru AB Inneh CA Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats Ibom Medical Journal Neurotoxicity Cadmium Mercury Locomotion Exploration Cerebellum |
| title | Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats |
| title_full | Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats |
| title_fullStr | Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats |
| title_full_unstemmed | Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats |
| title_short | Cadmium and Mercury Exposure: Oxidative, Neurobehavioural and Histological Alterations to the Cerebellum of Wistar Rats |
| title_sort | cadmium and mercury exposure oxidative neurobehavioural and histological alterations to the cerebellum of wistar rats |
| topic | Neurotoxicity Cadmium Mercury Locomotion Exploration Cerebellum |
| url | https://ibommedicaljournal.org/index.php/imjhome/article/view/252 |
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