Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles
Abstract Background Whether menstrual variability in women with regular and ovulatory cycle could affect embryo implantation remains controversial, with conflicting evidences presented in the literature. Thus, in this study, we evaluated the impact of prolonged follicular phase length (FPL) on the c...
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| Language: | English |
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BMC
2020-07-01
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| Series: | Journal of Ovarian Research |
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| Online Access: | http://link.springer.com/article/10.1186/s13048-020-00690-z |
| _version_ | 1797969707315232768 |
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| author | Ying Ying Fuman Qiu Qing Huang Sichen Li Haiying Liu Jianqiao Liu |
| author_facet | Ying Ying Fuman Qiu Qing Huang Sichen Li Haiying Liu Jianqiao Liu |
| author_sort | Ying Ying |
| collection | DOAJ |
| description | Abstract Background Whether menstrual variability in women with regular and ovulatory cycle could affect embryo implantation remains controversial, with conflicting evidences presented in the literature. Thus, in this study, we evaluated the impact of prolonged follicular phase length (FPL) on the clinical pregnancy rate (CPR) after frozen–thawed embryo transfer (FET) in true natural cycles (NC). Methods This retrospective cohort study utilized data from a large university-affiliated reproductive medicine center. Women undergoing true NC-FET were grouped as per their FPL type: Prolonged FPL (n = 127) and Normal FPL (n = 737). The primary study outcome was CPR in these 2 groups. Results The FPL in the current cycle was significantly longer in the Prolonged FPL group (23.0 ± 2.4) than in the Normal FPL group (16.0 ± 2.2; p < 0.001). The crude CPR was significantly higher in the Prolonged FPL group (61.4%) than in the Normal FPL group (51.7%; p = 0.043). After adjusting for the results of potential confounders including the age, BMI, percent of optimal embryos transferred, and endometrial thickness, the difference in the CRP between the 2 groups disappeared (OR 1.28, 95% CI: 0.86–1.91, p = 0.232). No statistically significant difference was noted in the rates of implantation and miscarriage. Conclusions The current FET should not be cancelled if the ovulation time exceeds the predicted period based on the length of the previous menstrual cycle in the light of no negative effect on the pregnancy outcome. |
| first_indexed | 2024-04-11T03:06:27Z |
| format | Article |
| id | doaj.art-b7fb980a45394a1e9da7cc76afad56aa |
| institution | Directory Open Access Journal |
| issn | 1757-2215 |
| language | English |
| last_indexed | 2024-04-11T03:06:27Z |
| publishDate | 2020-07-01 |
| publisher | BMC |
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| series | Journal of Ovarian Research |
| spelling | doaj.art-b7fb980a45394a1e9da7cc76afad56aa2023-01-02T13:08:32ZengBMCJournal of Ovarian Research1757-22152020-07-011311610.1186/s13048-020-00690-zFollicular phase length has no influence on frozen-thawed embryo transfers in natural cyclesYing Ying0Fuman Qiu1Qing Huang2Sichen Li3Haiying Liu4Jianqiao Liu5Reproductive Medicine Center, The Third Affiliated Hospital of Guangzhou Medical UniversityThe State Key Lab of Respiratory Disease, Collaborative Innovation Center for Environmental Toxicity, The School of Public Health, Guangzhou Medical UniversityReproductive Medicine Center, The Third Affiliated Hospital of Guangzhou Medical UniversityReproductive Medicine Center, The Third Affiliated Hospital of Guangzhou Medical UniversityReproductive Medicine Center, The Third Affiliated Hospital of Guangzhou Medical UniversityReproductive Medicine Center, The Third Affiliated Hospital of Guangzhou Medical UniversityAbstract Background Whether menstrual variability in women with regular and ovulatory cycle could affect embryo implantation remains controversial, with conflicting evidences presented in the literature. Thus, in this study, we evaluated the impact of prolonged follicular phase length (FPL) on the clinical pregnancy rate (CPR) after frozen–thawed embryo transfer (FET) in true natural cycles (NC). Methods This retrospective cohort study utilized data from a large university-affiliated reproductive medicine center. Women undergoing true NC-FET were grouped as per their FPL type: Prolonged FPL (n = 127) and Normal FPL (n = 737). The primary study outcome was CPR in these 2 groups. Results The FPL in the current cycle was significantly longer in the Prolonged FPL group (23.0 ± 2.4) than in the Normal FPL group (16.0 ± 2.2; p < 0.001). The crude CPR was significantly higher in the Prolonged FPL group (61.4%) than in the Normal FPL group (51.7%; p = 0.043). After adjusting for the results of potential confounders including the age, BMI, percent of optimal embryos transferred, and endometrial thickness, the difference in the CRP between the 2 groups disappeared (OR 1.28, 95% CI: 0.86–1.91, p = 0.232). No statistically significant difference was noted in the rates of implantation and miscarriage. Conclusions The current FET should not be cancelled if the ovulation time exceeds the predicted period based on the length of the previous menstrual cycle in the light of no negative effect on the pregnancy outcome.http://link.springer.com/article/10.1186/s13048-020-00690-zFollicular phase lengthFrozen–thawed embryo transferNatural cycle |
| spellingShingle | Ying Ying Fuman Qiu Qing Huang Sichen Li Haiying Liu Jianqiao Liu Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles Journal of Ovarian Research Follicular phase length Frozen–thawed embryo transfer Natural cycle |
| title | Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles |
| title_full | Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles |
| title_fullStr | Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles |
| title_full_unstemmed | Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles |
| title_short | Follicular phase length has no influence on frozen-thawed embryo transfers in natural cycles |
| title_sort | follicular phase length has no influence on frozen thawed embryo transfers in natural cycles |
| topic | Follicular phase length Frozen–thawed embryo transfer Natural cycle |
| url | http://link.springer.com/article/10.1186/s13048-020-00690-z |
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