Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer
Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the asso...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2019-07-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fonc.2019.00566/full |
| _version_ | 1818692045550649344 |
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| author | Seul A. Lee Fang Liu Stephen M. Riordan Cheok S. Lee Cheok S. Lee Cheok S. Lee Cheok S. Lee Li Zhang |
| author_facet | Seul A. Lee Fang Liu Stephen M. Riordan Cheok S. Lee Cheok S. Lee Cheok S. Lee Cheok S. Lee Li Zhang |
| author_sort | Seul A. Lee |
| collection | DOAJ |
| description | Colorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions. |
| first_indexed | 2024-12-17T12:51:33Z |
| format | Article |
| id | doaj.art-b7fbeb68edf84ded902fb84e3e742134 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-17T12:51:33Z |
| publishDate | 2019-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-b7fbeb68edf84ded902fb84e3e7421342022-12-21T21:47:35ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2019-07-01910.3389/fonc.2019.00566469862Global Investigations of Fusobacterium nucleatum in Human Colorectal CancerSeul A. Lee0Fang Liu1Stephen M. Riordan2Cheok S. Lee3Cheok S. Lee4Cheok S. Lee5Cheok S. Lee6Li Zhang7School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaGastrointestinal and Liver Unit, Prince of Wales Hospital, University of New South Wales, Sydney, NSW, AustraliaDiscipline of Pathology, School of Medicine, Western Sydney University, Sydney, NSW, AustraliaFaculty of Medicine and Health, Central Clinical School, University of Sydney, Sydney, NSW, AustraliaFaculty of Medicine, South Western Sydney Clinical School, University of New South Wales, Sydney, NSW, AustraliaDepartment of Anatomical Pathology, Liverpool Hospital, Sydney, NSW, AustraliaSchool of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, AustraliaColorectal cancer (CRC) is the third most prevalent cancer and second in terms of mortality. Emerging evidence from recent studies suggests a potential role of Fusobacterium nucleatum in the development of CRC. In this article, we review studies from different geographical regions examining the association between F. nucleatum and CRC, the detection methods and the tumorigenic mechanisms. Furthermore, we discuss the potential clinical impact of F. nucleatum in CRC and suggest future study directions.https://www.frontiersin.org/article/10.3389/fonc.2019.00566/fullcolorectal cancerCRCFusobacterium nucleatumF. nucleatumtumorigenic mechanisms |
| spellingShingle | Seul A. Lee Fang Liu Stephen M. Riordan Cheok S. Lee Cheok S. Lee Cheok S. Lee Cheok S. Lee Li Zhang Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer Frontiers in Oncology colorectal cancer CRC Fusobacterium nucleatum F. nucleatum tumorigenic mechanisms |
| title | Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer |
| title_full | Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer |
| title_fullStr | Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer |
| title_full_unstemmed | Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer |
| title_short | Global Investigations of Fusobacterium nucleatum in Human Colorectal Cancer |
| title_sort | global investigations of fusobacterium nucleatum in human colorectal cancer |
| topic | colorectal cancer CRC Fusobacterium nucleatum F. nucleatum tumorigenic mechanisms |
| url | https://www.frontiersin.org/article/10.3389/fonc.2019.00566/full |
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