TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia.

TGF-β Blockade Reduces Mortality and Metabolic Changes in a Validated Murine Model of Pancreatic Cancer Cachexia.

Cancer cachexia is a debilitating condition characterized by a combination of anorexia, muscle wasting, weight loss, and malnutrition. This condition affects an overwhelming majority of patients with pancreatic cancer and is a primary cause of cancer-related death. However, few, if any, effective th...

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Bibliographic Details
Main Authors: Stephanie H Greco, Lena Tomkötter, Anne-Kristin Vahle, Rae Rokosh, Antonina Avanzi, Syed Kashif Mahmood, Michael Deutsch, Sara Alothman, Dalia Alqunaibit, Atsuo Ochi, Constantinos Zambirinis, Tasnima Mohaimin, Mauricio Rendon, Elliot Levie, Mridul Pansari, Alejandro Torres-Hernandez, Donnele Daley, Rocky Barilla, H Leon Pachter, Daniel Tippens, Hassan Malik, Allal Boutajangout, Thomas Wisniewski, George Miller
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0132786

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