Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients
Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis. Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal contro...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
College of Medicine University of Baghdad
2009-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1170 |
| Summary: | Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis.
Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor.
Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out. |
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| ISSN: | 0041-9419 2410-8057 |