Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients
Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis. Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal contro...
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| Format: | Article |
| Language: | English |
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College of Medicine University of Baghdad
2009-04-01
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| Series: | مجلة كلية الطب |
| Subjects: | |
| Online Access: | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1170 |
| _version_ | 1797369475964600320 |
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| author | Eman Sh. AL-Obeidy Khalida M. Mousawy Raghad J H AL-Akayshi Laith A. Kamil |
| author_facet | Eman Sh. AL-Obeidy Khalida M. Mousawy Raghad J H AL-Akayshi Laith A. Kamil |
| author_sort | Eman Sh. AL-Obeidy |
| collection | DOAJ |
| description | Background: genetic factors were considered to play a possible role the development of autoimmune hepatitis.
Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls.
Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor.
Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out. |
| first_indexed | 2024-03-08T17:47:23Z |
| format | Article |
| id | doaj.art-b7fe099f974446f7b5750aac73999ded |
| institution | Directory Open Access Journal |
| issn | 0041-9419 2410-8057 |
| language | English |
| last_indexed | 2024-03-08T17:47:23Z |
| publishDate | 2009-04-01 |
| publisher | College of Medicine University of Baghdad |
| record_format | Article |
| series | مجلة كلية الطب |
| spelling | doaj.art-b7fe099f974446f7b5750aac73999ded2024-01-02T10:19:24ZengCollege of Medicine University of Baghdadمجلة كلية الطب0041-94192410-80572009-04-0151110.32007/1170%g42-46Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patientsEman Sh. AL-Obeidy0Khalida M. Mousawy1Raghad J H AL-Akayshi2Laith A. Kamil3Medical city.Medical College/ University of Baghdad.Gasteroentestinal and Hepatology Teaching Hospital.Al-Karama Teaching HospitalBackground: genetic factors were considered to play a possible role the development of autoimmune hepatitis. Patients and methods: polymerase chain reaction-sequence specific primers (PCRSSP) was the method used to asses HLA-typing of 100 blood samples of 60 AIH patients and 40 healthy normal controls. Results: comparison between AIH patients and healthy controls showed several antigens deviations in their frequencies. HLA-A*113 (A1/-/Null) observed to play a possible risk factor in this disease while significant loss of HLA-A*2 allele were clearly observed which prompt us to believe that it could act as a protective factor, on the other hand, increased frequency of HLA-B*8 & B*14 were statistically significant in AIH which is most likely to be considered as a rather risk factor, while most HLA-B*16 were lost which led us to think of being acting as a rather protective factor. Conclusions: this finding reflects a preliminary picture that HLA antigens might play a role in AIH susceptibility and further studies are worth being carried out.http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1170AIH, HLA antigen, PCR-SSP. |
| spellingShingle | Eman Sh. AL-Obeidy Khalida M. Mousawy Raghad J H AL-Akayshi Laith A. Kamil Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients مجلة كلية الطب AIH, HLA antigen, PCR-SSP. |
| title | Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients |
| title_full | Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients |
| title_fullStr | Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients |
| title_full_unstemmed | Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients |
| title_short | Possible association of HLA class-I Molecules with autoimmune Hepatitis in Iraqi patients |
| title_sort | possible association of hla class i molecules with autoimmune hepatitis in iraqi patients |
| topic | AIH, HLA antigen, PCR-SSP. |
| url | http://iqjmc.uobaghdad.edu.iq/index.php/19JFacMedBaghdad36/article/view/1170 |
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