Genome organization in cardiomyocytes expressing mutated A-type lamins
Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly to the heart failure epidemic, which represen...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-10-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2022.1030950/full |
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| author | Marie Kervella Maureen Jahier Albano C. Meli Antoine Muchir |
| author_facet | Marie Kervella Maureen Jahier Albano C. Meli Antoine Muchir |
| author_sort | Marie Kervella |
| collection | DOAJ |
| description | Cardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly to the heart failure epidemic, which represents a staggering clinical and public health problem worldwide. Gene mutations have been identified in 35% of patients with dilated cardiomyopathy. Pathogenic variants in LMNA, encoding nuclear A-type lamins, are one of the major causative causes of dilated cardiomyopathy (i.e. CardioLaminopathy). A-type lamins are type V intermediate filament proteins, which are the main components of the nuclear lamina. The nuclear lamina is connected to the cytoskeleton on one side, and to the chromatin on the other side. Among the models proposed to explain how CardioLaminopathy arises, the “chromatin model” posits an effect of mutated A-type lamins on the 3D genome organization and thus on the transcription activity of tissue-specific genes. Chromatin contacts with the nuclear lamina via specific genomic regions called lamina-associated domains lamina-associated domains. These LADs play a role in the chromatin organization and gene expression regulation. This review focuses on the identification of LADs and chromatin remodeling in cardiac muscle cells expressing mutated A-type lamins and discusses the methods and relevance of these findings in disease. |
| first_indexed | 2024-04-11T17:09:27Z |
| format | Article |
| id | doaj.art-b7ff68354deb4ed4af99500f91c6b65f |
| institution | Directory Open Access Journal |
| issn | 2296-634X |
| language | English |
| last_indexed | 2024-04-11T17:09:27Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj.art-b7ff68354deb4ed4af99500f91c6b65f2022-12-22T04:12:57ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2022-10-011010.3389/fcell.2022.10309501030950Genome organization in cardiomyocytes expressing mutated A-type laminsMarie Kervella0Maureen Jahier1Albano C. Meli2Antoine Muchir3PhyMedExp, University of Montpellier, INSERM, CNRS, Montpellier, FranceSorbonne Université, INSERM U974, Institute of Myology, Center of Research in Myology, Paris, FrancePhyMedExp, University of Montpellier, INSERM, CNRS, Montpellier, FranceSorbonne Université, INSERM U974, Institute of Myology, Center of Research in Myology, Paris, FranceCardiomyopathy is a myocardial disorder, in which the heart muscle is structurally and functionally abnormal, often leading to heart failure. Dilated cardiomyopathy is characterized by a compromised left ventricular function and contributes significantly to the heart failure epidemic, which represents a staggering clinical and public health problem worldwide. Gene mutations have been identified in 35% of patients with dilated cardiomyopathy. Pathogenic variants in LMNA, encoding nuclear A-type lamins, are one of the major causative causes of dilated cardiomyopathy (i.e. CardioLaminopathy). A-type lamins are type V intermediate filament proteins, which are the main components of the nuclear lamina. The nuclear lamina is connected to the cytoskeleton on one side, and to the chromatin on the other side. Among the models proposed to explain how CardioLaminopathy arises, the “chromatin model” posits an effect of mutated A-type lamins on the 3D genome organization and thus on the transcription activity of tissue-specific genes. Chromatin contacts with the nuclear lamina via specific genomic regions called lamina-associated domains lamina-associated domains. These LADs play a role in the chromatin organization and gene expression regulation. This review focuses on the identification of LADs and chromatin remodeling in cardiac muscle cells expressing mutated A-type lamins and discusses the methods and relevance of these findings in disease.https://www.frontiersin.org/articles/10.3389/fcell.2022.1030950/fullLMNAnuclear laminscardiomyopathygenome organizationLADslamina-associated domains |
| spellingShingle | Marie Kervella Maureen Jahier Albano C. Meli Antoine Muchir Genome organization in cardiomyocytes expressing mutated A-type lamins Frontiers in Cell and Developmental Biology LMNA nuclear lamins cardiomyopathy genome organization LADs lamina-associated domains |
| title | Genome organization in cardiomyocytes expressing mutated A-type lamins |
| title_full | Genome organization in cardiomyocytes expressing mutated A-type lamins |
| title_fullStr | Genome organization in cardiomyocytes expressing mutated A-type lamins |
| title_full_unstemmed | Genome organization in cardiomyocytes expressing mutated A-type lamins |
| title_short | Genome organization in cardiomyocytes expressing mutated A-type lamins |
| title_sort | genome organization in cardiomyocytes expressing mutated a type lamins |
| topic | LMNA nuclear lamins cardiomyopathy genome organization LADs lamina-associated domains |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2022.1030950/full |
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