Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway

Effects of HDAC inhibitors on neuroblastoma SH-SY5Y cell differentiation into mature neurons via the Wnt signaling pathway

Abstract Histone deacetylase (HDAC) inhibitors affect cell homeostasis, gene expression, and cell cycle progression and promote cell terminal differentiation or apoptosis. However, the effect of HDAC inhibition on SH-SY5Y cells, which are neuroblastoma cells capable of differentiating into neurons u...

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Bibliographic Details
Main Authors: Jiyun Choi, Jinsu Hwang, Mahesh Ramalingam, Han-Seong Jeong, Sujeong Jang
Format: Article
Language:English
Published: BMC 2023-05-01
Series:BMC Neuroscience
Subjects:
HDAC inhibitor
MS275
VPA
Neuronal differentiation
Wnt signaling pathway
Online Access:https://doi.org/10.1186/s12868-023-00798-0

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