Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes
Inflammation impacts human hematopoiesis across physiologic and pathologic conditions, as signals derived from the bone marrow microenvironment, such as pro-inflammatory cytokines and chemokines, have been shown to alter hematopoietic stem cell (HSCs) homeostasis. Dysregulated inflammation can skew...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-09-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/10/2613 |
| _version_ | 1827721632262651904 |
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| author | Veronica Vallelonga Francesco Gandolfi Francesca Ficara Matteo Giovanni Della Porta Serena Ghisletti |
| author_facet | Veronica Vallelonga Francesco Gandolfi Francesca Ficara Matteo Giovanni Della Porta Serena Ghisletti |
| author_sort | Veronica Vallelonga |
| collection | DOAJ |
| description | Inflammation impacts human hematopoiesis across physiologic and pathologic conditions, as signals derived from the bone marrow microenvironment, such as pro-inflammatory cytokines and chemokines, have been shown to alter hematopoietic stem cell (HSCs) homeostasis. Dysregulated inflammation can skew HSC fate-related decisions, leading to aberrant hematopoiesis and potentially contributing to the pathogenesis of hematological disorders such as myelodysplastic syndromes (MDS). Recently, emerging studies have used single-cell sequencing and muti-omic approaches to investigate HSC cellular heterogeneity and gene expression in normal hematopoiesis as well as in myeloid malignancies. This review summarizes recent reports mechanistically dissecting the role of inflammatory signaling and innate immune response activation due to MDS progression. Furthermore, we highlight the growing importance of using multi-omic techniques, such as single-cell profiling and deconvolution methods, to unravel MDSs’ heterogeneity. These approaches have provided valuable insights into the patterns of clonal evolution that drive MDS progression and have elucidated the impact of inflammation on the composition of the bone marrow immune microenvironment in MDS. |
| first_indexed | 2024-03-10T21:25:48Z |
| format | Article |
| id | doaj.art-b802d1fa812b4b88a900e473c65a824e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T21:25:48Z |
| publishDate | 2023-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-b802d1fa812b4b88a900e473c65a824e2023-11-19T15:44:32ZengMDPI AGBiomedicines2227-90592023-09-011110261310.3390/biomedicines11102613Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic SyndromesVeronica Vallelonga0Francesco Gandolfi1Francesca Ficara2Matteo Giovanni Della Porta3Serena Ghisletti4Department of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, 20139 Milan, ItalyDepartment of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, 20139 Milan, ItalyMilan Unit, CNR-IRGB, 20090 Milan, ItalyIRCCS Humanitas Research Hospital, 20089 Milan, ItalyDepartment of Experimental Oncology, European Institute of Oncology (IEO) IRCCS, 20139 Milan, ItalyInflammation impacts human hematopoiesis across physiologic and pathologic conditions, as signals derived from the bone marrow microenvironment, such as pro-inflammatory cytokines and chemokines, have been shown to alter hematopoietic stem cell (HSCs) homeostasis. Dysregulated inflammation can skew HSC fate-related decisions, leading to aberrant hematopoiesis and potentially contributing to the pathogenesis of hematological disorders such as myelodysplastic syndromes (MDS). Recently, emerging studies have used single-cell sequencing and muti-omic approaches to investigate HSC cellular heterogeneity and gene expression in normal hematopoiesis as well as in myeloid malignancies. This review summarizes recent reports mechanistically dissecting the role of inflammatory signaling and innate immune response activation due to MDS progression. Furthermore, we highlight the growing importance of using multi-omic techniques, such as single-cell profiling and deconvolution methods, to unravel MDSs’ heterogeneity. These approaches have provided valuable insights into the patterns of clonal evolution that drive MDS progression and have elucidated the impact of inflammation on the composition of the bone marrow immune microenvironment in MDS.https://www.mdpi.com/2227-9059/11/10/2613inflammationhematopoiesisMDSHSCsc-RNAseqsc-ATACseq |
| spellingShingle | Veronica Vallelonga Francesco Gandolfi Francesca Ficara Matteo Giovanni Della Porta Serena Ghisletti Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes Biomedicines inflammation hematopoiesis MDS HSC sc-RNAseq sc-ATACseq |
| title | Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes |
| title_full | Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes |
| title_fullStr | Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes |
| title_full_unstemmed | Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes |
| title_short | Emerging Insights into Molecular Mechanisms of Inflammation in Myelodysplastic Syndromes |
| title_sort | emerging insights into molecular mechanisms of inflammation in myelodysplastic syndromes |
| topic | inflammation hematopoiesis MDS HSC sc-RNAseq sc-ATACseq |
| url | https://www.mdpi.com/2227-9059/11/10/2613 |
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