An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses
Sinonasal undifferentiated carcinoma (SNUC) of the paranasal sinuses represents a very rare and extremely aggressive malignancy posing a diagnostic and therapeutic dilemma for treating physicians due to its location, vast array of differential diagnosis without any definite therapeutic guideline. Wi...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2016-01-01
|
| Series: | Archives of Medicine and Health Sciences |
| Subjects: | |
| Online Access: | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2016;volume=4;issue=2;spage=225;epage=228;aulast=Purkayastha |
| _version_ | 1828357144509939712 |
|---|---|
| author | Abhishek Purkayastha Neelam Sharma Tejas Pandya Chhavi Arora |
| author_facet | Abhishek Purkayastha Neelam Sharma Tejas Pandya Chhavi Arora |
| author_sort | Abhishek Purkayastha |
| collection | DOAJ |
| description | Sinonasal undifferentiated carcinoma (SNUC) of the paranasal sinuses represents a very rare and extremely aggressive malignancy posing a diagnostic and therapeutic dilemma for treating physicians due to its location, vast array of differential diagnosis without any definite therapeutic guideline. With only a few cases described in the literature, we hereby report a 34-year-old male with progressive, painless swelling of the left eye and diminution of vision. Radiographic imaging showed a mass lesion in the left anterior ethmoid sinus. Biopsy of nasal mass seen on nasal endoscopy revealed a poorly differentiated malignancy. He underwent craniotomy and excision of tumor. Postoperative histopathology report showed SNUC staining positive for epithelial membrane antigen, neuron-specific enolase, and cytokeratin on immunohistochemistry. He received postoperative radiotherapy (RT) and chemotherapy but developed extensive skeletal metastasis, for which he was treated with palliative RT to which he responded well. At present, he was on close follow-up with a Karnofsky performance status of 60%. |
| first_indexed | 2024-04-14T03:10:47Z |
| format | Article |
| id | doaj.art-b803299647b94d4aa2734cb7e6bfcafc |
| institution | Directory Open Access Journal |
| issn | 2321-4848 |
| language | English |
| last_indexed | 2024-04-14T03:10:47Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Archives of Medicine and Health Sciences |
| spelling | doaj.art-b803299647b94d4aa2734cb7e6bfcafc2022-12-22T02:15:36ZengWolters Kluwer Medknow PublicationsArchives of Medicine and Health Sciences2321-48482016-01-014222522810.4103/2321-4848.196203An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinusesAbhishek PurkayasthaNeelam SharmaTejas PandyaChhavi AroraSinonasal undifferentiated carcinoma (SNUC) of the paranasal sinuses represents a very rare and extremely aggressive malignancy posing a diagnostic and therapeutic dilemma for treating physicians due to its location, vast array of differential diagnosis without any definite therapeutic guideline. With only a few cases described in the literature, we hereby report a 34-year-old male with progressive, painless swelling of the left eye and diminution of vision. Radiographic imaging showed a mass lesion in the left anterior ethmoid sinus. Biopsy of nasal mass seen on nasal endoscopy revealed a poorly differentiated malignancy. He underwent craniotomy and excision of tumor. Postoperative histopathology report showed SNUC staining positive for epithelial membrane antigen, neuron-specific enolase, and cytokeratin on immunohistochemistry. He received postoperative radiotherapy (RT) and chemotherapy but developed extensive skeletal metastasis, for which he was treated with palliative RT to which he responded well. At present, he was on close follow-up with a Karnofsky performance status of 60%.http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2016;volume=4;issue=2;spage=225;epage=228;aulast=PurkayasthaChemotherapypalliationparanasal sinusesradiotherapysinonasal undifferentiated carcinoma |
| spellingShingle | Abhishek Purkayastha Neelam Sharma Tejas Pandya Chhavi Arora An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses Archives of Medicine and Health Sciences Chemotherapy palliation paranasal sinuses radiotherapy sinonasal undifferentiated carcinoma |
| title | An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses |
| title_full | An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses |
| title_fullStr | An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses |
| title_full_unstemmed | An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses |
| title_short | An extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses |
| title_sort | extremely rare case report of sinonasal undifferentiated carcinoma of paranasal sinuses |
| topic | Chemotherapy palliation paranasal sinuses radiotherapy sinonasal undifferentiated carcinoma |
| url | http://www.amhsjournal.org/article.asp?issn=2321-4848;year=2016;volume=4;issue=2;spage=225;epage=228;aulast=Purkayastha |
| work_keys_str_mv | AT abhishekpurkayastha anextremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT neelamsharma anextremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT tejaspandya anextremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT chhaviarora anextremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT abhishekpurkayastha extremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT neelamsharma extremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT tejaspandya extremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses AT chhaviarora extremelyrarecasereportofsinonasalundifferentiatedcarcinomaofparanasalsinuses |