Increased Ca2+ signaling in NRXN1α +/− neurons derived from ASD induced pluripotent stem cells

Increased Ca2+ signaling in NRXN1α +/− neurons derived from ASD induced pluripotent stem cells

Abstract Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a high co-morbidity of epilepsy and associated with hundreds of rare risk factors. NRXN1 deletion is among the commonest rare genetic factors shared by ASD, schizophrenia, intellectual disability, epilepsy, and...

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Main Authors: Sahar Avazzadeh, Katya McDonagh, Jamie Reilly, Yanqin Wang, Stephanie D. Boomkamp, Veronica McInerney, Janusz Krawczyk, Jacqueline Fitzgerald, Niamh Feerick, Matthew O’Sullivan, Amirhossein Jalali, Eva B. Forman, Sally A. Lynch, Sean Ennis, Nele Cosemans, Hilde Peeters, Peter Dockery, Timothy O’Brien, Leo R. Quinlan, Louise Gallagher, Sanbing Shen
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Molecular Autism
Subjects:
Autism
Calcium signaling
Induced pluripotent stem cells
Neurons
NRXN1α
Transcriptome
Online Access:https://doi.org/10.1186/s13229-019-0303-3

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