Roles of CCL2-CCR2 Axis in the Tumor Microenvironment
Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/22/16/8530 |
| _version_ | 1797523658793549824 |
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| author | Suguru Kadomoto Kouji Izumi Atsushi Mizokami |
| author_facet | Suguru Kadomoto Kouji Izumi Atsushi Mizokami |
| author_sort | Suguru Kadomoto |
| collection | DOAJ |
| description | Chemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy. |
| first_indexed | 2024-03-10T08:46:10Z |
| format | Article |
| id | doaj.art-b803dc1bbb244893a9defbd7fe4486c9 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T08:46:10Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-b803dc1bbb244893a9defbd7fe4486c92023-11-22T07:56:32ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-08-012216853010.3390/ijms22168530Roles of CCL2-CCR2 Axis in the Tumor MicroenvironmentSuguru Kadomoto0Kouji Izumi1Atsushi Mizokami2Department of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 13-1 Takara-machi, Ishikawa 920-8641, JapanDepartment of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 13-1 Takara-machi, Ishikawa 920-8641, JapanDepartment of Integrative Cancer Therapy and Urology, Graduate School of Medical Science, Kanazawa University, Kanazawa, 13-1 Takara-machi, Ishikawa 920-8641, JapanChemokines are a small family of cytokines that were first discovered as chemotactic factors in leukocytes during inflammation, and reports on the relationship between chemokines and cancer progression have recently been increasing. The CCL2-CCR2 axis is one of the major chemokine signaling pathways, and has various functions in tumor progression, such as increasing tumor cell proliferation and invasiveness, and creating a tumor microenvironment through increased angiogenesis and recruitment of immunosuppressive cells. This review discusses the roles of the CCL2-CCR2 axis and the tumor microenvironment in cancer progression and their future roles in cancer therapy.https://www.mdpi.com/1422-0067/22/16/8530chemokinesCCL2-CCR2 axistumor microenvironment |
| spellingShingle | Suguru Kadomoto Kouji Izumi Atsushi Mizokami Roles of CCL2-CCR2 Axis in the Tumor Microenvironment International Journal of Molecular Sciences chemokines CCL2-CCR2 axis tumor microenvironment |
| title | Roles of CCL2-CCR2 Axis in the Tumor Microenvironment |
| title_full | Roles of CCL2-CCR2 Axis in the Tumor Microenvironment |
| title_fullStr | Roles of CCL2-CCR2 Axis in the Tumor Microenvironment |
| title_full_unstemmed | Roles of CCL2-CCR2 Axis in the Tumor Microenvironment |
| title_short | Roles of CCL2-CCR2 Axis in the Tumor Microenvironment |
| title_sort | roles of ccl2 ccr2 axis in the tumor microenvironment |
| topic | chemokines CCL2-CCR2 axis tumor microenvironment |
| url | https://www.mdpi.com/1422-0067/22/16/8530 |
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