Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus

Downregulation of neurodevelopmental gene expression in iPSC-derived cerebral organoids upon infection by human cytomegalovirus

Summary: Human cytomegalovirus (HCMV) is a betaherpesvirus that can cause severe birth defects including vision and hearing loss, microcephaly, and seizures. Currently, no approved treatment options exist for in utero infections. Here, we aimed to determine the impact of HCMV infection on the transc...

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Bibliographic Details
Main Authors: Benjamin S. O’Brien, Rebekah L. Mokry, Megan L. Schumacher, Kirthi Pulakanti, Sridhar Rao, Scott S. Terhune, Allison D. Ebert
Format: Article
Language:English
Published: Elsevier 2022-04-01
Series:iScience
Subjects:
Biotechnology
Developmental neuroscience
Transcriptomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004222003686

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