The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa?
Aims of the studyThe study aims to identify the differences in brain activity between participants with anorexia nervosa and healthy control using visual stimulus conditions combined with the quantitative dense-array EEG recording analysis method called Brain Activation Sequences (BAS).Materials and...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-10-01
|
| Series: | Frontiers in Psychology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.958501/full |
| _version_ | 1811194710343024640 |
|---|---|
| author | Marek Susta Gustav Bizik Anna Yamamotova Svojmil Petranek Marie Kadochova Hana Papezova |
| author_facet | Marek Susta Gustav Bizik Anna Yamamotova Svojmil Petranek Marie Kadochova Hana Papezova |
| author_sort | Marek Susta |
| collection | DOAJ |
| description | Aims of the studyThe study aims to identify the differences in brain activity between participants with anorexia nervosa and healthy control using visual stimulus conditions combined with the quantitative dense-array EEG recording analysis method called Brain Activation Sequences (BAS).Materials and methods23 participants with anorexia nervosa and 21 healthy controls were presented with visual stimuli, including the subject’s facial expressions and body images. The 128-channel EEG data were processed using BAS and displayed as activity in up to 66 brain regions. Subsequent cluster analysis was used to identify groups of participants exhibiting area-specific activation patterns.ResultsCluster analysis identified three distinct groups: one including all healthy controls (HC) and two consisting of all participants with anorexia (AN-I with 19 participants and AN-II with four participants). The AN-I and AN-II groups differed in their response to treatment. Comparisons of HC vs. AN confirmed the dominance of the right cerebral hemisphere in participants with anorexia nervosa in two of the three reported conditions. The facial expressions condition, specifically the facial reaction expressing disgust, indicates the existence of a social attentional bias toward faces, whereas emotions remained undetected in participants. High limbic activity, medial frontal gyrus involvement, low fusiform cortex activity, and milder visual cortex activity in healthy controls compared to participants indicate that the facial expression stimulus is perceived by healthy subjects primarily as an emotion, not as the face itself. In the body image condition, participants showed higher activity in the fusiform gyrus and right insula, indicating activation of the brain’s “fear network.”ConclusionThe study describes a specific pattern of brain activation in response to facial expression of disgust and body images that likely contributes to social-cognitive and behavioral impairments in anorexia. In addition, the substantial difference in the pattern of brain activation within the participants with AN and its association with treatment resistance deserves special attention because of its potential to develop a clinically useful prediction tool and identify potential targets for, for example, neuromodulatory treatments and/or individualized psychotherapy. |
| first_indexed | 2024-04-12T00:31:14Z |
| format | Article |
| id | doaj.art-b8058383676a4878a32ff2360bc11a2f |
| institution | Directory Open Access Journal |
| issn | 1664-1078 |
| language | English |
| last_indexed | 2024-04-12T00:31:14Z |
| publishDate | 2022-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychology |
| spelling | doaj.art-b8058383676a4878a32ff2360bc11a2f2022-12-22T03:55:20ZengFrontiers Media S.A.Frontiers in Psychology1664-10782022-10-011310.3389/fpsyg.2022.958501958501The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa?Marek Susta0Gustav Bizik1Anna Yamamotova2Svojmil Petranek3Marie Kadochova4Hana Papezova5Department of Public Health, St. Elisabeth University, Bratislava, SlovakiaDepartment of Psychiatry, Aalborg University Hospital, Aalborg, DenmarkDepartment of Physiology, Third Faculty of Medicine, Charles University, Prague, CzechiaHealth Care Facility, Department of the Interior, Prague, CzechiaDepartment of Public Health, St. Elisabeth University, Bratislava, SlovakiaDepartment of Psychiatry, First Faculty of Medicine, Charles University and General University Hospital, Prague, CzechiaAims of the studyThe study aims to identify the differences in brain activity between participants with anorexia nervosa and healthy control using visual stimulus conditions combined with the quantitative dense-array EEG recording analysis method called Brain Activation Sequences (BAS).Materials and methods23 participants with anorexia nervosa and 21 healthy controls were presented with visual stimuli, including the subject’s facial expressions and body images. The 128-channel EEG data were processed using BAS and displayed as activity in up to 66 brain regions. Subsequent cluster analysis was used to identify groups of participants exhibiting area-specific activation patterns.ResultsCluster analysis identified three distinct groups: one including all healthy controls (HC) and two consisting of all participants with anorexia (AN-I with 19 participants and AN-II with four participants). The AN-I and AN-II groups differed in their response to treatment. Comparisons of HC vs. AN confirmed the dominance of the right cerebral hemisphere in participants with anorexia nervosa in two of the three reported conditions. The facial expressions condition, specifically the facial reaction expressing disgust, indicates the existence of a social attentional bias toward faces, whereas emotions remained undetected in participants. High limbic activity, medial frontal gyrus involvement, low fusiform cortex activity, and milder visual cortex activity in healthy controls compared to participants indicate that the facial expression stimulus is perceived by healthy subjects primarily as an emotion, not as the face itself. In the body image condition, participants showed higher activity in the fusiform gyrus and right insula, indicating activation of the brain’s “fear network.”ConclusionThe study describes a specific pattern of brain activation in response to facial expression of disgust and body images that likely contributes to social-cognitive and behavioral impairments in anorexia. In addition, the substantial difference in the pattern of brain activation within the participants with AN and its association with treatment resistance deserves special attention because of its potential to develop a clinically useful prediction tool and identify potential targets for, for example, neuromodulatory treatments and/or individualized psychotherapy.https://www.frontiersin.org/articles/10.3389/fpsyg.2022.958501/fullanorexia nervosaqEEGtreatment responsefacial expressionsperceptiondisgust |
| spellingShingle | Marek Susta Gustav Bizik Anna Yamamotova Svojmil Petranek Marie Kadochova Hana Papezova The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa? Frontiers in Psychology anorexia nervosa qEEG treatment response facial expressions perception disgust |
| title | The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa? |
| title_full | The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa? |
| title_fullStr | The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa? |
| title_full_unstemmed | The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa? |
| title_short | The sight of one’s own body: Could qEEG help predict the treatment response in anorexia nervosa? |
| title_sort | sight of one s own body could qeeg help predict the treatment response in anorexia nervosa |
| topic | anorexia nervosa qEEG treatment response facial expressions perception disgust |
| url | https://www.frontiersin.org/articles/10.3389/fpsyg.2022.958501/full |
| work_keys_str_mv | AT mareksusta thesightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT gustavbizik thesightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT annayamamotova thesightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT svojmilpetranek thesightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT mariekadochova thesightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT hanapapezova thesightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT mareksusta sightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT gustavbizik sightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT annayamamotova sightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT svojmilpetranek sightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT mariekadochova sightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa AT hanapapezova sightofonesownbodycouldqeeghelppredictthetreatmentresponseinanorexianervosa |