Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept
Abstract Background The use of Spectral domain optical coherence tomography (SD-OCT) to evaluate the predictors of visual acuity-recovery in patients treated with conbercept for macular edema (ME) secondary to central retinal vein occlusion (CRVO) has rarely been seen. We collected 26 CRVO-ME patien...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Ophthalmology |
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| Online Access: | https://doi.org/10.1186/s12886-021-02174-0 |
| _version_ | 1818752649552461824 |
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| author | Qi Zhang Yinfen Hou Xiao Cao Rongrong Zhang Yinping Liu Chenghua Wei Changfan Wu Lixin Mei Pengfei Zhang |
| author_facet | Qi Zhang Yinfen Hou Xiao Cao Rongrong Zhang Yinping Liu Chenghua Wei Changfan Wu Lixin Mei Pengfei Zhang |
| author_sort | Qi Zhang |
| collection | DOAJ |
| description | Abstract Background The use of Spectral domain optical coherence tomography (SD-OCT) to evaluate the predictors of visual acuity-recovery in patients treated with conbercept for macular edema (ME) secondary to central retinal vein occlusion (CRVO) has rarely been seen. We collected 26 CRVO-ME patients with different OCT measures at 6 months follow-up to identify the factors that are most strongly correlated with the best-corrected visual acuity (BCVA) post-treatment in CRVO-ME patients treated with conbercept. Purpose To evaluate the effectiveness of intravitreal conbercept injections for the treatment of CRVO-ME and to determine the major predictors of best-corrected visual acuity (BCVA) post-treatment. Methods A retrospective study methodology was used. Twenty-six eyes from 26 patients with CRVO-ME were enrolled in the study. After an initial intravitreal injection of conbercept (0.5 mg/0.05 ml), monthly injections for up to 6 months were given following a 1 + PRN (pro re nata) regimen. Data collected at monthly intervals included measurements of the logMAR BCVA, central subfield thickness (CST), macular volume (MV), photoreceptor layer thickness (PLT), outer nuclear layer thickness (ONLT), and the disrupted ellipsoid zone (DEZ). The correlation between BCVA, before and after injections, and each of CST, MV, PLT, ONLT, DEZ was analyzed. Results The logMAR BCVA in months 3 and 6 post-injection was significantly improved relative to the baseline. In this same period the CST, MV, PLT, ONLT and DEZ were also significantly improved relative to the baseline. There was a negative correlation between PLT and logMAR BCVA at months 3 and 6 after treatment (r = − 0.549, P < 0.001; r = − 0.087, P < 0.001). Conclusion Intravitreal injection of conbercept is an effective treatment for CRVO-ME. With 6 months of follow-up, logMAR BCVA and CST, MV, PLT, ONLT, DEZ improved. PLT was negatively correlated with the visual function in CRVO-ME patients after conbercept treatment, which may be a predictor of vision recovery in patients with CRVO-ME. |
| first_indexed | 2024-12-18T04:54:49Z |
| format | Article |
| id | doaj.art-b805cbff053144d38333f10fb51a1f40 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-12-18T04:54:49Z |
| publishDate | 2021-11-01 |
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| series | BMC Ophthalmology |
| spelling | doaj.art-b805cbff053144d38333f10fb51a1f402022-12-21T21:20:20ZengBMCBMC Ophthalmology1471-24152021-11-012111710.1186/s12886-021-02174-0Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with ConberceptQi Zhang0Yinfen Hou1Xiao Cao2Rongrong Zhang3Yinping Liu4Chenghua Wei5Changfan Wu6Lixin Mei7Pengfei Zhang8Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Department of Ophthalmology, The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital of Wannan Medical College)Abstract Background The use of Spectral domain optical coherence tomography (SD-OCT) to evaluate the predictors of visual acuity-recovery in patients treated with conbercept for macular edema (ME) secondary to central retinal vein occlusion (CRVO) has rarely been seen. We collected 26 CRVO-ME patients with different OCT measures at 6 months follow-up to identify the factors that are most strongly correlated with the best-corrected visual acuity (BCVA) post-treatment in CRVO-ME patients treated with conbercept. Purpose To evaluate the effectiveness of intravitreal conbercept injections for the treatment of CRVO-ME and to determine the major predictors of best-corrected visual acuity (BCVA) post-treatment. Methods A retrospective study methodology was used. Twenty-six eyes from 26 patients with CRVO-ME were enrolled in the study. After an initial intravitreal injection of conbercept (0.5 mg/0.05 ml), monthly injections for up to 6 months were given following a 1 + PRN (pro re nata) regimen. Data collected at monthly intervals included measurements of the logMAR BCVA, central subfield thickness (CST), macular volume (MV), photoreceptor layer thickness (PLT), outer nuclear layer thickness (ONLT), and the disrupted ellipsoid zone (DEZ). The correlation between BCVA, before and after injections, and each of CST, MV, PLT, ONLT, DEZ was analyzed. Results The logMAR BCVA in months 3 and 6 post-injection was significantly improved relative to the baseline. In this same period the CST, MV, PLT, ONLT and DEZ were also significantly improved relative to the baseline. There was a negative correlation between PLT and logMAR BCVA at months 3 and 6 after treatment (r = − 0.549, P < 0.001; r = − 0.087, P < 0.001). Conclusion Intravitreal injection of conbercept is an effective treatment for CRVO-ME. With 6 months of follow-up, logMAR BCVA and CST, MV, PLT, ONLT, DEZ improved. PLT was negatively correlated with the visual function in CRVO-ME patients after conbercept treatment, which may be a predictor of vision recovery in patients with CRVO-ME.https://doi.org/10.1186/s12886-021-02174-0CRVO-MEConberceptBest corrected visual acuity, predictive factor |
| spellingShingle | Qi Zhang Yinfen Hou Xiao Cao Rongrong Zhang Yinping Liu Chenghua Wei Changfan Wu Lixin Mei Pengfei Zhang Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept BMC Ophthalmology CRVO-ME Conbercept Best corrected visual acuity, predictive factor |
| title | Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept |
| title_full | Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept |
| title_fullStr | Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept |
| title_full_unstemmed | Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept |
| title_short | Predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with Conbercept |
| title_sort | predictors of visual recovery in patients with macular edema secondary to central retinal vein occlusion after treatment with conbercept |
| topic | CRVO-ME Conbercept Best corrected visual acuity, predictive factor |
| url | https://doi.org/10.1186/s12886-021-02174-0 |
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