PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS
Currently, there is a marked tendency towards improvement of early detection of breast cancer that allows patients at extremely low risk for developing recurrent disease to be identified. Therefore, it is necessary to search for biological markers of unfavorable prognosis for patients with hormone-d...
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| 格式: | 文件 |
| 语言: | Russian |
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Russian Academy of Sciences, Tomsk National Research Medical Center
2016-02-01
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| 丛编: | Сибирский онкологический журнал |
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| 在线阅读: | https://www.siboncoj.ru/jour/article/view/181 |
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| author | M. V. Rodionova I. K. Vorotnikov V. V. Rodionov E. A. Dudko N. V. Chkhivadze V. V. Kometova D. A. Ryabchikov E. V. Oshkina A. S. Ozherelyev T. А. Bogush |
| author_facet | M. V. Rodionova I. K. Vorotnikov V. V. Rodionov E. A. Dudko N. V. Chkhivadze V. V. Kometova D. A. Ryabchikov E. V. Oshkina A. S. Ozherelyev T. А. Bogush |
| author_sort | M. V. Rodionova |
| collection | DOAJ |
| description | Currently, there is a marked tendency towards improvement of early detection of breast cancer that allows patients at extremely low risk for developing recurrent disease to be identified. Therefore, it is necessary to search for biological markers of unfavorable prognosis for patients with hormone-dependent breast cancer. In order to introduce these markers into routine clinical practice, they should be validated in welldesigned clinical studies, provide additional predictive information and be easily reproducible. The standard immunohistochemical parameters (estrogen and progesterone receptors and Ki67 cell proliferation index) can be served as these markers. However, the dynamic changes in these parameters during hormone therapyrather than their initial expression levels in the tumor are of great significance for the individualized hormone therapy. |
| first_indexed | 2024-04-10T01:54:37Z |
| format | Article |
| id | doaj.art-b808022ffac24f1092c3c4309a2dfc82 |
| institution | Directory Open Access Journal |
| issn | 1814-4861 2312-3168 |
| language | Russian |
| last_indexed | 2025-03-14T10:10:03Z |
| publishDate | 2016-02-01 |
| publisher | Russian Academy of Sciences, Tomsk National Research Medical Center |
| record_format | Article |
| series | Сибирский онкологический журнал |
| spelling | doaj.art-b808022ffac24f1092c3c4309a2dfc822025-03-02T11:16:05ZrusRussian Academy of Sciences, Tomsk National Research Medical CenterСибирский онкологический журнал1814-48612312-31682016-02-0115102109181PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTSM. V. Rodionova0I. K. Vorotnikov1V. V. Rodionov2E. A. Dudko3N. V. Chkhivadze4V. V. Kometova5D. A. Ryabchikov6E. V. Oshkina7A. S. Ozherelyev8T. А. Bogush9N.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowUlyanovsk State UniversityN.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowUlyanovsk State UniversityN.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowN.N. Blokhin Russian Cancer Research Center, MoscowCurrently, there is a marked tendency towards improvement of early detection of breast cancer that allows patients at extremely low risk for developing recurrent disease to be identified. Therefore, it is necessary to search for biological markers of unfavorable prognosis for patients with hormone-dependent breast cancer. In order to introduce these markers into routine clinical practice, they should be validated in welldesigned clinical studies, provide additional predictive information and be easily reproducible. The standard immunohistochemical parameters (estrogen and progesterone receptors and Ki67 cell proliferation index) can be served as these markers. However, the dynamic changes in these parameters during hormone therapyrather than their initial expression levels in the tumor are of great significance for the individualized hormone therapy.https://www.siboncoj.ru/jour/article/view/181breast cancer, hormone therapy, ki67, hormone sensitivity |
| spellingShingle | M. V. Rodionova I. K. Vorotnikov V. V. Rodionov E. A. Dudko N. V. Chkhivadze V. V. Kometova D. A. Ryabchikov E. V. Oshkina A. S. Ozherelyev T. А. Bogush PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS Сибирский онкологический журнал breast cancer, hormone therapy, ki67, hormone sensitivity |
| title | PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS |
| title_full | PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS |
| title_fullStr | PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS |
| title_full_unstemmed | PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS |
| title_short | PROGNOSTIC AND PREDICTIVE SIGNIFICANCE OF KI67 DYNAMIC CHANGE DURING PREOPERATIVE ENDOCRINE THERAPY IN BREAST CNACER PATIENTS |
| title_sort | prognostic and predictive significance of ki67 dynamic change during preoperative endocrine therapy in breast cnacer patients |
| topic | breast cancer, hormone therapy, ki67, hormone sensitivity |
| url | https://www.siboncoj.ru/jour/article/view/181 |
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