Determination and Pharmacokinetic Study of Three Diterpenes in Rat Plasma by UHPLC-ESI-MS/MS after Oral Administration of Rosmarinus officinalis L. Extract

Determination and Pharmacokinetic Study of Three Diterpenes in Rat Plasma by UHPLC-ESI-MS/MS after Oral Administration of Rosmarinus officinalis L. Extract

Rosmarinus officinalis L. is commonly used as a spice and flavoring agent. Diterpenes are the main active compounds of R. officinalis. An Ultra High Performance Liquid Chromatography-Tandem Mass Spectrometry (UHPLC-ESI-MS/MS) method was developed for the determination of carnosol, rosmanol, and carn...

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Bibliographic Details
Main Authors: Liqian Wang, Chunli Gan, Zhibin Wang, Lu Liu, Mingjie Gao, Qian Li, Chunjuan Yang
Format: Article
Language:English
Published: MDPI AG 2017-06-01
Series:Molecules
Subjects:
Rosmarinus officinalis L.
UHPLC/MS/MS
diterpenes
pharmacokinetics
Online Access:http://www.mdpi.com/1420-3049/22/6/934

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