Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension
Objective To explore the differences in clinical indicators and clinicopathological characteristics immunoglobulin A nephropathy (IgAN) patients with hypertension accompanied with arteriolar hyalinosis and those without. Methods A total of 246 patients who was diagnosed with biopsy-proven primary Ig...
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Editorial Office of Journal of Third Military Medical University
2022-04-01
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| Series: | Di-san junyi daxue xuebao |
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| Online Access: | http://aammt.tmmu.edu.cn/Upload/rhtml/202201103.htm |
| _version_ | 1818127762232180736 |
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| author | SHEN Yunzhu XIONG Jiachuan ZHAO Jinghong |
| author_facet | SHEN Yunzhu XIONG Jiachuan ZHAO Jinghong |
| author_sort | SHEN Yunzhu |
| collection | DOAJ |
| description | Objective To explore the differences in clinical indicators and clinicopathological characteristics immunoglobulin A nephropathy (IgAN) patients with hypertension accompanied with arteriolar hyalinosis and those without. Methods A total of 246 patients who was diagnosed with biopsy-proven primary IgAN and hypertension in our hospital from 2012 to 2018 were enrolled in our study. According to the severity of arteriolar hyalinosis, they were divided into 3 groups, without (n=73) and with mild (n=136, severity: 1%~25%) and moderate arteriolar hyalinosis (n=37, severity: 26%~50%), respectively. The correlations of clinicopathological parameters with arteriolar hyalinosis were analyzed in the groups. Results The incidence (55.3%) of mild arteriolar hyalinosis was the highest in the patients. There were significant differences in tumor necrosis factor-α (TNF-α), urea, serum creatinine (Scr), uric acid, and estimated glomerular filtration rate (eGFR) among the 3 groups (P < 0.05). In clinicopathological parameters, glomerulosclerosis, mesangial hypercellularity (M), segmental sclerosis (S), and interstitial fibrosis/tubular atrophy (T) lesions and grades of Lee classification differed statistically among the 3 groups (P < 0.05). Moreover, correlation analysis showed that arteriolar hyalinosis had a strong positive correlation with grade of Lee classification (rs=0.433, P < 0.001), Scr (rs=0.319, P < 0.001) and T (V=0.317, P < 0.001), respectively, while a strong negative correlation with eGFR (rs=-0.367, P < 0.001). Conclusion Significant differences are observed in clinical and pathological indicators in patients with IgAN and hypertension accompanied with arteriolar hyalinosis or not. Its severity is closely associated with renal function, so arteriolar hyalinosis can be used as an indicator to evaluate the function. |
| first_indexed | 2024-12-11T07:22:30Z |
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| language | zho |
| last_indexed | 2024-12-11T07:22:30Z |
| publishDate | 2022-04-01 |
| publisher | Editorial Office of Journal of Third Military Medical University |
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| series | Di-san junyi daxue xuebao |
| spelling | doaj.art-b80db48d42744470a7032390fcfa1d732022-12-22T01:16:04ZzhoEditorial Office of Journal of Third Military Medical UniversityDi-san junyi daxue xuebao1000-54042022-04-0144880581110.16016/j.2097-0927.202201103Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertensionSHEN Yunzhu0XIONG Jiachuan1ZHAO Jinghong2Department of Nephrology, PLA Center for Nephrology, Chongqing Key Laboratory for Prevention and Treatment of Chronic Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Nephrology, PLA Center for Nephrology, Chongqing Key Laboratory for Prevention and Treatment of Chronic Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaDepartment of Nephrology, PLA Center for Nephrology, Chongqing Key Laboratory for Prevention and Treatment of Chronic Kidney Disease, Chongqing Clinical Research Center of Kidney and Urology Diseases, Second Affiliated Hospital, Army Medical University (Third Military Medical University), Chongqing, 400037, ChinaObjective To explore the differences in clinical indicators and clinicopathological characteristics immunoglobulin A nephropathy (IgAN) patients with hypertension accompanied with arteriolar hyalinosis and those without. Methods A total of 246 patients who was diagnosed with biopsy-proven primary IgAN and hypertension in our hospital from 2012 to 2018 were enrolled in our study. According to the severity of arteriolar hyalinosis, they were divided into 3 groups, without (n=73) and with mild (n=136, severity: 1%~25%) and moderate arteriolar hyalinosis (n=37, severity: 26%~50%), respectively. The correlations of clinicopathological parameters with arteriolar hyalinosis were analyzed in the groups. Results The incidence (55.3%) of mild arteriolar hyalinosis was the highest in the patients. There were significant differences in tumor necrosis factor-α (TNF-α), urea, serum creatinine (Scr), uric acid, and estimated glomerular filtration rate (eGFR) among the 3 groups (P < 0.05). In clinicopathological parameters, glomerulosclerosis, mesangial hypercellularity (M), segmental sclerosis (S), and interstitial fibrosis/tubular atrophy (T) lesions and grades of Lee classification differed statistically among the 3 groups (P < 0.05). Moreover, correlation analysis showed that arteriolar hyalinosis had a strong positive correlation with grade of Lee classification (rs=0.433, P < 0.001), Scr (rs=0.319, P < 0.001) and T (V=0.317, P < 0.001), respectively, while a strong negative correlation with eGFR (rs=-0.367, P < 0.001). Conclusion Significant differences are observed in clinical and pathological indicators in patients with IgAN and hypertension accompanied with arteriolar hyalinosis or not. Its severity is closely associated with renal function, so arteriolar hyalinosis can be used as an indicator to evaluate the function.http://aammt.tmmu.edu.cn/Upload/rhtml/202201103.htmimmunoglobulin a nephropathyhypertensionarteriolar hyalinosiscorrelation analysis |
| spellingShingle | SHEN Yunzhu XIONG Jiachuan ZHAO Jinghong Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension Di-san junyi daxue xuebao immunoglobulin a nephropathy hypertension arteriolar hyalinosis correlation analysis |
| title | Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension |
| title_full | Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension |
| title_fullStr | Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension |
| title_full_unstemmed | Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension |
| title_short | Correlation of arteriolar hyalinosis and clinicopathological features in patients with IgA nephropathy and hypertension |
| title_sort | correlation of arteriolar hyalinosis and clinicopathological features in patients with iga nephropathy and hypertension |
| topic | immunoglobulin a nephropathy hypertension arteriolar hyalinosis correlation analysis |
| url | http://aammt.tmmu.edu.cn/Upload/rhtml/202201103.htm |
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