Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion
This comprehensive review examines the unique attributes, distinctions, and clinical implications of ceftazidime–avibactam (CAZ-AVI) and meropenem–vaborbactam (MEM-VAB) against difficult-to-treat <i>Enterobacterales</i> infections. Our manuscript explores these antibiotics’ pharmacokinet...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2023-10-01
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| Series: | Antibiotics |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2079-6382/12/10/1521 |
| _version_ | 1827722001709531136 |
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| author | Andrea Marino Edoardo Campanella Stefano Stracquadanio Maddalena Calvo Giuseppe Migliorisi Alice Nicolosi Federica Cosentino Stefano Marletta Serena Spampinato Pamela Prestifilippo Stefania Stefani Bruno Cacopardo Giuseppe Nunnari |
| author_facet | Andrea Marino Edoardo Campanella Stefano Stracquadanio Maddalena Calvo Giuseppe Migliorisi Alice Nicolosi Federica Cosentino Stefano Marletta Serena Spampinato Pamela Prestifilippo Stefania Stefani Bruno Cacopardo Giuseppe Nunnari |
| author_sort | Andrea Marino |
| collection | DOAJ |
| description | This comprehensive review examines the unique attributes, distinctions, and clinical implications of ceftazidime–avibactam (CAZ-AVI) and meropenem–vaborbactam (MEM-VAB) against difficult-to-treat <i>Enterobacterales</i> infections. Our manuscript explores these antibiotics’ pharmacokinetic and pharmacodynamic properties, antimicrobial activities, in vitro susceptibility testing, and clinical data. Moreover, it includes a meticulous examination of comparative clinical and microbiological studies, assessed and presented to provide clarity in making informed treatment choices for clinicians. Finally, we propose an expert opinion from a microbiological and a clinical point of view about their use in appropriate clinical settings. This is the first review aiming to provide healthcare professionals with valuable insights for making informed treatment decisions when combating carbapenem-resistant pathogens. |
| first_indexed | 2024-03-10T21:29:40Z |
| format | Article |
| id | doaj.art-b80f4840982742e9b5dd28d5f1469a9e |
| institution | Directory Open Access Journal |
| issn | 2079-6382 |
| language | English |
| last_indexed | 2024-03-10T21:29:40Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Antibiotics |
| spelling | doaj.art-b80f4840982742e9b5dd28d5f1469a9e2023-11-19T15:26:40ZengMDPI AGAntibiotics2079-63822023-10-011210152110.3390/antibiotics12101521Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert OpinionAndrea Marino0Edoardo Campanella1Stefano Stracquadanio2Maddalena Calvo3Giuseppe Migliorisi4Alice Nicolosi5Federica Cosentino6Stefano Marletta7Serena Spampinato8Pamela Prestifilippo9Stefania Stefani10Bruno Cacopardo11Giuseppe Nunnari12Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyU.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-Vittorio Emanuele”, Via S. Sofia 78, 95123 Catania, ItalyU.O.C. Laboratory Analysis Unit, A.O.U. “Policlinico-Vittorio Emanuele”, Via S. Sofia 78, 95123 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyUnit of Infectious Diseases, ARNAS Garibaldi Hospital, University of Catania, 95122 Catania, ItalyDepartment of Diagnostic and Public Health, Section of Pathology, University of Verona, 37124 Verona, ItalyUnit of Infectious Diseases, Department of Clinical and Experimental Medicine, University of Messina, 98124 Messina, ItalyIntensive Care Unit, ARNAS Garibaldi Hospital, 95122 Catania, ItalyDepartment of Biomedical and Biotechnological Sciences, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyDepartment of Clinical and Experimental Medicine, University of Catania, 95123 Catania, ItalyThis comprehensive review examines the unique attributes, distinctions, and clinical implications of ceftazidime–avibactam (CAZ-AVI) and meropenem–vaborbactam (MEM-VAB) against difficult-to-treat <i>Enterobacterales</i> infections. Our manuscript explores these antibiotics’ pharmacokinetic and pharmacodynamic properties, antimicrobial activities, in vitro susceptibility testing, and clinical data. Moreover, it includes a meticulous examination of comparative clinical and microbiological studies, assessed and presented to provide clarity in making informed treatment choices for clinicians. Finally, we propose an expert opinion from a microbiological and a clinical point of view about their use in appropriate clinical settings. This is the first review aiming to provide healthcare professionals with valuable insights for making informed treatment decisions when combating carbapenem-resistant pathogens.https://www.mdpi.com/2079-6382/12/10/1521ceftazidime–avibactammeropenem–vaborbactamcarbapenem-resistant <i>Enterobacterales</i>carbapenemasesGram-negative infectionsnew BL/BLICs |
| spellingShingle | Andrea Marino Edoardo Campanella Stefano Stracquadanio Maddalena Calvo Giuseppe Migliorisi Alice Nicolosi Federica Cosentino Stefano Marletta Serena Spampinato Pamela Prestifilippo Stefania Stefani Bruno Cacopardo Giuseppe Nunnari Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion Antibiotics ceftazidime–avibactam meropenem–vaborbactam carbapenem-resistant <i>Enterobacterales</i> carbapenemases Gram-negative infections new BL/BLICs |
| title | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion |
| title_full | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion |
| title_fullStr | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion |
| title_full_unstemmed | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion |
| title_short | Ceftazidime/Avibactam and Meropenem/Vaborbactam for the Management of Enterobacterales Infections: A Narrative Review, Clinical Considerations, and Expert Opinion |
| title_sort | ceftazidime avibactam and meropenem vaborbactam for the management of enterobacterales infections a narrative review clinical considerations and expert opinion |
| topic | ceftazidime–avibactam meropenem–vaborbactam carbapenem-resistant <i>Enterobacterales</i> carbapenemases Gram-negative infections new BL/BLICs |
| url | https://www.mdpi.com/2079-6382/12/10/1521 |
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