Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman
Objectives: This study aimed to determine the prevalence of vitamin B12 deficiency amongst diabetic patients on metformin therapy. Methods: This cross-sectional study was conducted at general clinics at the University Health Center and diabetes outpatient clinics at Sultan Qaboos University Hospital...
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| Format: | Article |
| Language: | English |
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Sultan Qaboos University
2020-03-01
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| Series: | Sultan Qaboos University Medical Journal |
| Online Access: | https://journals.squ.edu.om/index.php/squmj/article/view/3512 |
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| author | Ahmed Al-Hamdi Mohammed Al-Gahhafi Shihab Al-Roshdi Sanjay Jaju Ali Al-Mamari Abdulaziz M. Al Mahrezi |
| author_facet | Ahmed Al-Hamdi Mohammed Al-Gahhafi Shihab Al-Roshdi Sanjay Jaju Ali Al-Mamari Abdulaziz M. Al Mahrezi |
| author_sort | Ahmed Al-Hamdi |
| collection | DOAJ |
| description | Objectives: This study aimed to determine the prevalence of vitamin B12 deficiency amongst diabetic patients on metformin therapy. Methods: This cross-sectional study was conducted at general clinics at the University Health Center and diabetes outpatient clinics at Sultan Qaboos University Hospital, Muscat, Oman, between January and December 2017. All Omani adults who were diagnosed with type 2 diabetes mellitus and took metformin were invited to participate in the study. The variables included in this study were age, gender, duration of diabetes, dose and duration of metformin therapy, haemoglobin and glycosylated haemoglobin level. Results: A total of 248 subjects were included (response rate = 95.4%) of which 26 (10.5%) were vitamin B12 deficient and 53 (21.4%) were borderline deficient. The mean daily dose of metformin was highest among vitamin B12 deficient group (1,981 ± 222 mg; P = 0.004). Conclusion: The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy. Further research is needed to confirm the need for routine screening and monitoring.
Keywords: Type 2 Diabetes Mellitus; Prevalence; Metformin; Vitamin B12 Deficiency; Oman. |
| first_indexed | 2024-04-12T20:21:49Z |
| format | Article |
| id | doaj.art-b8131a647f374fd9839907acb4d53d51 |
| institution | Directory Open Access Journal |
| issn | 2075-051X 2075-0528 |
| language | English |
| last_indexed | 2024-04-12T20:21:49Z |
| publishDate | 2020-03-01 |
| publisher | Sultan Qaboos University |
| record_format | Article |
| series | Sultan Qaboos University Medical Journal |
| spelling | doaj.art-b8131a647f374fd9839907acb4d53d512022-12-22T03:17:59ZengSultan Qaboos UniversitySultan Qaboos University Medical Journal2075-051X2075-05282020-03-01201909410.18295/squmj.2020.20.01.0132754Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from OmanAhmed Al-Hamdi0Mohammed Al-Gahhafi1Shihab Al-Roshdi2Sanjay Jaju3Ali Al-Mamari4Abdulaziz M. Al Mahrezi5Directorate of Health Services of North Batinah, Ministry of Health, Sohar, OmanDirectorate General of Health Services of North Sharqiya, Ministry of Health, Mudhaibi, OmanDirectorate of Health Services of North Batinah, Ministry of Health, Saham, OmanDepartment of Family Medicine & Public Health, Sultan Qaboos University, Muscat, OmanDepartment of Medicine, Sultan Qaboos University, Muscat, OmanDepartment of Family Medicine & Public Health, Sultan Qaboos University Hospital, Muscat, OmanObjectives: This study aimed to determine the prevalence of vitamin B12 deficiency amongst diabetic patients on metformin therapy. Methods: This cross-sectional study was conducted at general clinics at the University Health Center and diabetes outpatient clinics at Sultan Qaboos University Hospital, Muscat, Oman, between January and December 2017. All Omani adults who were diagnosed with type 2 diabetes mellitus and took metformin were invited to participate in the study. The variables included in this study were age, gender, duration of diabetes, dose and duration of metformin therapy, haemoglobin and glycosylated haemoglobin level. Results: A total of 248 subjects were included (response rate = 95.4%) of which 26 (10.5%) were vitamin B12 deficient and 53 (21.4%) were borderline deficient. The mean daily dose of metformin was highest among vitamin B12 deficient group (1,981 ± 222 mg; P = 0.004). Conclusion: The prevalence of vitamin B12 deficiency is considerable among diabetic patients on metformin therapy. Further research is needed to confirm the need for routine screening and monitoring. Keywords: Type 2 Diabetes Mellitus; Prevalence; Metformin; Vitamin B12 Deficiency; Oman.https://journals.squ.edu.om/index.php/squmj/article/view/3512 |
| spellingShingle | Ahmed Al-Hamdi Mohammed Al-Gahhafi Shihab Al-Roshdi Sanjay Jaju Ali Al-Mamari Abdulaziz M. Al Mahrezi Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman Sultan Qaboos University Medical Journal |
| title | Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman |
| title_full | Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman |
| title_fullStr | Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman |
| title_full_unstemmed | Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman |
| title_short | Vitamin B12 Deficiency in Diabetic Patients on Metformin Therapy: A cross-sectional study from Oman |
| title_sort | vitamin b12 deficiency in diabetic patients on metformin therapy a cross sectional study from oman |
| url | https://journals.squ.edu.om/index.php/squmj/article/view/3512 |
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