Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells

Sox2 promotes expression of the ST6Gal-I glycosyltransferase in ovarian cancer cells

Abstract Background The ST6Gal-I glycosyltransferase, which adds α2–6-linked sialic acids to N-glycosylated proteins is upregulated in a wide range of malignancies including ovarian cancer. Prior studies have shown that ST6Gal-I-mediated sialylation of select surface receptors remodels intracellular...

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Bibliographic Details
Main Authors: Kaitlyn A. Dorsett, Robert B. Jones, Katherine E. Ankenbauer, Anita B. Hjelmeland, Susan L. Bellis
Format: Article
Language:English
Published: BMC 2019-10-01
Series:Journal of Ovarian Research
Subjects:
Sialic acid
ST6Gal-I
Sox2
3q26 amplicon
Cancer stem cells
Ovarian cancer
Online Access:http://link.springer.com/article/10.1186/s13048-019-0574-5

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http://link.springer.com/article/10.1186/s13048-019-0574-5

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