The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine
The severe acute respiratory syndrome coronavirus - 2 (SARS - CoV - 2) was reported to cause the Wuhan outbreak of the corona virus disease 2019(COVID-19). To date, the COVID-19 has infected more than 600 million people gloabally. As a growing number of patients recover from acute infections and are...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-01-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.1054312/full |
| _version_ | 1797956398730969088 |
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| author | Linlin Jiang Linlin Jiang Xuedong An Yingying Duan Yingying Duan Fengmei Lian De Jin Yuehong Zhang Cunqing Yang Yuqing Zhang Xiaomin Kang Xiaomin Kang Yuting Sun |
| author_facet | Linlin Jiang Linlin Jiang Xuedong An Yingying Duan Yingying Duan Fengmei Lian De Jin Yuehong Zhang Cunqing Yang Yuqing Zhang Xiaomin Kang Xiaomin Kang Yuting Sun |
| author_sort | Linlin Jiang |
| collection | DOAJ |
| description | The severe acute respiratory syndrome coronavirus - 2 (SARS - CoV - 2) was reported to cause the Wuhan outbreak of the corona virus disease 2019(COVID-19). To date, the COVID-19 has infected more than 600 million people gloabally. As a growing number of patients recover from acute infections and are discharged from hospitals, the proportion of patients in the recovery period is gradually increasing. Many of these individuals have been reported to experience multiple symptoms during the convalescence, such as fatigue, dyspnea and pain which are designated as “long-COVID”, “post-COVID syndrome” or “recovery sequelae. We searched for recent articles published in PubMed on COVID-19 convalescence and found that the pathogenesis of COVID-19 convalescence is not yet well recognized. It may be associated with incomplete recovery of immune system, parenchymal organ damage (liver or lung), coagulation abnormalities, “second hit” caused by viral infection, and Phenomenon of Cell Senescence-Associated Secretory Phenotype (SASP). Some drugs and psychological factors of patients also play a non-negligible role in it. We also found that the effect of traditional Chinese medicine (TCM) is effective in the treatment of the COVID-19 recovery phase, which can not only relieve the corresponding symptoms, but also improve the indicators and pulmonary fibrosis. Bufei Huoxue Capsule, as the only drug explicitly mentioned for COVID-19 recovery period, can exert strong rehabilitative effects on physiological activity in patients recovering from COVID-19. In addition, in previous studies, traditional Chinese medicine has been confirmed to have the ability to resist cytokine storms, as well as improve coagulation and myocardial damage, which makes it have potential therapeutic advantages in targeting the hyperimmune response, coagulation abnormalities and myocardial damage existing in the recovery period. In conclusion, the clinical symptoms of patients convalescing from COVID-19 are complex, and its pathogenesis has not been elucidated. traditional Chinese medicine, as a traditional treatment, its specific action and mechanism need to be confirmed by more studies, so that it can play a better role. |
| first_indexed | 2024-04-10T23:48:25Z |
| format | Article |
| id | doaj.art-b8194ae0d8ea4ad9a9e6c4ea6660512c |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-04-10T23:48:25Z |
| publishDate | 2023-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-b8194ae0d8ea4ad9a9e6c4ea6660512c2023-01-10T21:51:04ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122023-01-011310.3389/fphar.2022.10543121054312The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicineLinlin Jiang0Linlin Jiang1Xuedong An2Yingying Duan3Yingying Duan4Fengmei Lian5De Jin6Yuehong Zhang7Cunqing Yang8Yuqing Zhang9Xiaomin Kang10Xiaomin Kang11Yuting Sun12Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing, ChinaGuang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaThe severe acute respiratory syndrome coronavirus - 2 (SARS - CoV - 2) was reported to cause the Wuhan outbreak of the corona virus disease 2019(COVID-19). To date, the COVID-19 has infected more than 600 million people gloabally. As a growing number of patients recover from acute infections and are discharged from hospitals, the proportion of patients in the recovery period is gradually increasing. Many of these individuals have been reported to experience multiple symptoms during the convalescence, such as fatigue, dyspnea and pain which are designated as “long-COVID”, “post-COVID syndrome” or “recovery sequelae. We searched for recent articles published in PubMed on COVID-19 convalescence and found that the pathogenesis of COVID-19 convalescence is not yet well recognized. It may be associated with incomplete recovery of immune system, parenchymal organ damage (liver or lung), coagulation abnormalities, “second hit” caused by viral infection, and Phenomenon of Cell Senescence-Associated Secretory Phenotype (SASP). Some drugs and psychological factors of patients also play a non-negligible role in it. We also found that the effect of traditional Chinese medicine (TCM) is effective in the treatment of the COVID-19 recovery phase, which can not only relieve the corresponding symptoms, but also improve the indicators and pulmonary fibrosis. Bufei Huoxue Capsule, as the only drug explicitly mentioned for COVID-19 recovery period, can exert strong rehabilitative effects on physiological activity in patients recovering from COVID-19. In addition, in previous studies, traditional Chinese medicine has been confirmed to have the ability to resist cytokine storms, as well as improve coagulation and myocardial damage, which makes it have potential therapeutic advantages in targeting the hyperimmune response, coagulation abnormalities and myocardial damage existing in the recovery period. In conclusion, the clinical symptoms of patients convalescing from COVID-19 are complex, and its pathogenesis has not been elucidated. traditional Chinese medicine, as a traditional treatment, its specific action and mechanism need to be confirmed by more studies, so that it can play a better role.https://www.frontiersin.org/articles/10.3389/fphar.2022.1054312/fullCOVID-19TCM (trad. Chinese medicine)recovery periodmechanismlong-COVID-19 |
| spellingShingle | Linlin Jiang Linlin Jiang Xuedong An Yingying Duan Yingying Duan Fengmei Lian De Jin Yuehong Zhang Cunqing Yang Yuqing Zhang Xiaomin Kang Xiaomin Kang Yuting Sun The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine Frontiers in Pharmacology COVID-19 TCM (trad. Chinese medicine) recovery period mechanism long-COVID-19 |
| title | The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine |
| title_full | The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine |
| title_fullStr | The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine |
| title_full_unstemmed | The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine |
| title_short | The pathological mechanism of the COVID-19 convalescence and its treatment with traditional Chinese medicine |
| title_sort | pathological mechanism of the covid 19 convalescence and its treatment with traditional chinese medicine |
| topic | COVID-19 TCM (trad. Chinese medicine) recovery period mechanism long-COVID-19 |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.1054312/full |
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