Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia
Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression.
| Main Authors: | , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2016-06-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/ncomms11960 |
| _version_ | 1818992640818937856 |
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| author | Xue Gao Shu-Hai Lin Feng Ren Jin-Tao Li Jia-Jia Chen Chuan-Bo Yao Hong-Bin Yang Shu-Xia Jiang Guo-Quan Yan Di Wang Yi Wang Ying Liu Zongwei Cai Ying-Ying Xu Jing Chen Wenqiang Yu Peng-Yuan Yang Qun-Ying Lei |
| author_facet | Xue Gao Shu-Hai Lin Feng Ren Jin-Tao Li Jia-Jia Chen Chuan-Bo Yao Hong-Bin Yang Shu-Xia Jiang Guo-Quan Yan Di Wang Yi Wang Ying Liu Zongwei Cai Ying-Ying Xu Jing Chen Wenqiang Yu Peng-Yuan Yang Qun-Ying Lei |
| author_sort | Xue Gao |
| collection | DOAJ |
| description | Cancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression. |
| first_indexed | 2024-12-20T20:29:23Z |
| format | Article |
| id | doaj.art-b8194c2aa98945ec80fb6bb93952191d |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T20:29:23Z |
| publishDate | 2016-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-b8194c2aa98945ec80fb6bb93952191d2022-12-21T19:27:23ZengNature PortfolioNature Communications2041-17232016-06-017111410.1038/ncomms11960Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxiaXue Gao0Shu-Hai Lin1Feng Ren2Jin-Tao Li3Jia-Jia Chen4Chuan-Bo Yao5Hong-Bin Yang6Shu-Xia Jiang7Guo-Quan Yan8Di Wang9Yi Wang10Ying Liu11Zongwei Cai12Ying-Ying Xu13Jing Chen14Wenqiang Yu15Peng-Yuan Yang16Qun-Ying Lei17and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan UniversityDepartment of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Shanghai Jiao Tong University School of Medicine (SJTU-SM)and Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan UniversityDepartment of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan UniversityDepartment of Pathology, School of Basic Medical Sciences, Fudan UniversityDepartment of Chemistry, State Key Laboratory of Environmental and Biological Analysis, Hong Kong Baptist Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan UniversityDepartment of Hematology and Medical Oncology, Winship Cancer Institute of Emory, Emory University School of Medicineand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan Universityand Department of Biochemistry and Molecular Biology, Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, School of Basic Medical Sciences, and Institutes of Biomedical Sciences, Fudan UniversityCancer cells under stress use acetate to maintain the acetyl-CoA pool and fuel lipid biosynthesis. Here, the authors show that acetate also promotes de novo lipid synthesis by increasing histone acetylation at the promoters of lipogenic enzymes ACACA and FASN, thus inducing their expression.https://doi.org/10.1038/ncomms11960 |
| spellingShingle | Xue Gao Shu-Hai Lin Feng Ren Jin-Tao Li Jia-Jia Chen Chuan-Bo Yao Hong-Bin Yang Shu-Xia Jiang Guo-Quan Yan Di Wang Yi Wang Ying Liu Zongwei Cai Ying-Ying Xu Jing Chen Wenqiang Yu Peng-Yuan Yang Qun-Ying Lei Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia Nature Communications |
| title | Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia |
| title_full | Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia |
| title_fullStr | Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia |
| title_full_unstemmed | Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia |
| title_short | Acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia |
| title_sort | acetate functions as an epigenetic metabolite to promote lipid synthesis under hypoxia |
| url | https://doi.org/10.1038/ncomms11960 |
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