Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report
Abstract Background Immunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, although there is concern that...
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| Format: | Article |
| Language: | English |
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BMC
2019-08-01
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| Series: | Italian Journal of Pediatrics |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s13052-019-0708-9 |
| _version_ | 1818407747700391936 |
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| author | Shuwen Zhong Jingqing Zeng Zhaohui Deng Lirong Jiang Bin Zhang Kaihua Yang Wenyu Wang Tianao Zhang |
| author_facet | Shuwen Zhong Jingqing Zeng Zhaohui Deng Lirong Jiang Bin Zhang Kaihua Yang Wenyu Wang Tianao Zhang |
| author_sort | Shuwen Zhong |
| collection | DOAJ |
| description | Abstract Background Immunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, although there is concern that IC patients may be at higher risk of infectious complications related to FMT. And reports of FMT in IC children are limited. Case presentation We describe two cases of FMT in IC children with refractory diarrhea. One IC child had polyendocrinopathy, enteropathy, X-linked syndrome and the other child had graft-versus-host disease. Both of the children had a long course of diarrhea and no response to traditional treatment. FMT was performed on both patients via nasojejunal tubes under guidance of gastroduodenoscopy. After FMT, the patients achieved remission of symptoms and neither of them had related infectious complications. Microbiota analysis showed that FMT resulted in reconstruction of a diverse microbiota. Conclusions Use of FMT is safe and effective in treatment of refractory diarrhea in IC children with a damaged microbiota. |
| first_indexed | 2024-12-14T09:32:45Z |
| format | Article |
| id | doaj.art-b81ab7ce28b141728dd226ea49f4c9a2 |
| institution | Directory Open Access Journal |
| issn | 1824-7288 |
| language | English |
| last_indexed | 2024-12-14T09:32:45Z |
| publishDate | 2019-08-01 |
| publisher | BMC |
| record_format | Article |
| series | Italian Journal of Pediatrics |
| spelling | doaj.art-b81ab7ce28b141728dd226ea49f4c9a22022-12-21T23:08:01ZengBMCItalian Journal of Pediatrics1824-72882019-08-014511610.1186/s13052-019-0708-9Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case reportShuwen Zhong0Jingqing Zeng1Zhaohui Deng2Lirong Jiang3Bin Zhang4Kaihua Yang5Wenyu Wang6Tianao Zhang7Department of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityDepartment of Pediatric Gastroenterology, Shanghai Children’s Medical Center, School of Medicine, Shanghai Jiao Tong UniversityAbstract Background Immunocompromised (IC) patients have an increased risk of refractory diarrhea. Fecal microbiota transplantation (FMT) is a safe and effective therapy for infection-related diarrhea which are mainly mediated by the loss of the microbial colonization, although there is concern that IC patients may be at higher risk of infectious complications related to FMT. And reports of FMT in IC children are limited. Case presentation We describe two cases of FMT in IC children with refractory diarrhea. One IC child had polyendocrinopathy, enteropathy, X-linked syndrome and the other child had graft-versus-host disease. Both of the children had a long course of diarrhea and no response to traditional treatment. FMT was performed on both patients via nasojejunal tubes under guidance of gastroduodenoscopy. After FMT, the patients achieved remission of symptoms and neither of them had related infectious complications. Microbiota analysis showed that FMT resulted in reconstruction of a diverse microbiota. Conclusions Use of FMT is safe and effective in treatment of refractory diarrhea in IC children with a damaged microbiota.http://link.springer.com/article/10.1186/s13052-019-0708-9Fecal microbiota transplantationRefractory diarrheaGraft-versus-host diseaseImmunocompromised children |
| spellingShingle | Shuwen Zhong Jingqing Zeng Zhaohui Deng Lirong Jiang Bin Zhang Kaihua Yang Wenyu Wang Tianao Zhang Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report Italian Journal of Pediatrics Fecal microbiota transplantation Refractory diarrhea Graft-versus-host disease Immunocompromised children |
| title | Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report |
| title_full | Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report |
| title_fullStr | Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report |
| title_full_unstemmed | Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report |
| title_short | Fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases: a pediatric case report |
| title_sort | fecal microbiota transplantation for refractory diarrhea in immunocompromised diseases a pediatric case report |
| topic | Fecal microbiota transplantation Refractory diarrhea Graft-versus-host disease Immunocompromised children |
| url | http://link.springer.com/article/10.1186/s13052-019-0708-9 |
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