Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats
Background: Carboplatin is one of the common chemotherapeutic agents in the management of various malignant conditions. Myelosuppression remains one of the major adverse effects of it that leads to compromised quality of life and can procrastinate or cease the chemotherapy regimen. Increasing shreds...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-07-01
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| Series: | Journal of Ayurveda and Integrative Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0975947622000584 |
| _version_ | 1817980127113379840 |
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| author | Santosh F. Patil Vishalaxi V. Shahapurkar Pukar Khanal |
| author_facet | Santosh F. Patil Vishalaxi V. Shahapurkar Pukar Khanal |
| author_sort | Santosh F. Patil |
| collection | DOAJ |
| description | Background: Carboplatin is one of the common chemotherapeutic agents in the management of various malignant conditions. Myelosuppression remains one of the major adverse effects of it that leads to compromised quality of life and can procrastinate or cease the chemotherapy regimen. Increasing shreds of evidence suggest the role of Complementary and alternate medicine in palliative cancer care. Ayurveda has prescribed Dooshivishari Agada (DVA) as an anti-dote for similar conditions mentioned above which arise out of sub-lethal toxic substances called Dooshivisha (DV). Objective: The present study was carried out to evaluate the role of DVA in myelosuppression among rats. Method: Male Wistar rats weighing 250–275 g were divided into three groups, Group I was administered normal saline and acted as Normal control. Group II and III received a single dose of carboplatin (60 mg/kg through the tail vein) on day one and acted as disease control. Group III received experimental drug DVA 256 mg/kg orally for the next 18 days. Animals were bled on days 0, 3, 6, 9, 12, 15, 18 for hematological analysis. Results: DVA prolonged the nadir time for Hb, RBC, and WBC counts from day 9 to day 12 when compared to the carboplatin group. In terms of Platelet count, there was no significant difference over carboplatin. Group III showed a significant increase in Total reticulocyte count in comparison to group II. Conclusion: Present study showed that DVA may help in delaying the myelosuppression which needs further evaluation. |
| first_indexed | 2024-04-13T22:50:35Z |
| format | Article |
| id | doaj.art-b81b790328b64c029a4d318e5cf82c9d |
| institution | Directory Open Access Journal |
| issn | 0975-9476 |
| language | English |
| last_indexed | 2024-04-13T22:50:35Z |
| publishDate | 2022-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Ayurveda and Integrative Medicine |
| spelling | doaj.art-b81b790328b64c029a4d318e5cf82c9d2022-12-22T02:26:13ZengElsevierJournal of Ayurveda and Integrative Medicine0975-94762022-07-01133100599Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar ratsSantosh F. Patil0Vishalaxi V. Shahapurkar1Pukar Khanal2Department of Agadatantra, KLEU Shri B M K Ayurveda Mahavidyalaya, Nath Pai Circle, Shahpur, Belagavi, Karnataka, 590003, India; Corresponding author.Department of Agadatantra, Shivalik Ayurveda Medical College, Azamgrah, Uttarpradesh, IndiaDepartment of Pharmacology, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore, 575018, IndiaBackground: Carboplatin is one of the common chemotherapeutic agents in the management of various malignant conditions. Myelosuppression remains one of the major adverse effects of it that leads to compromised quality of life and can procrastinate or cease the chemotherapy regimen. Increasing shreds of evidence suggest the role of Complementary and alternate medicine in palliative cancer care. Ayurveda has prescribed Dooshivishari Agada (DVA) as an anti-dote for similar conditions mentioned above which arise out of sub-lethal toxic substances called Dooshivisha (DV). Objective: The present study was carried out to evaluate the role of DVA in myelosuppression among rats. Method: Male Wistar rats weighing 250–275 g were divided into three groups, Group I was administered normal saline and acted as Normal control. Group II and III received a single dose of carboplatin (60 mg/kg through the tail vein) on day one and acted as disease control. Group III received experimental drug DVA 256 mg/kg orally for the next 18 days. Animals were bled on days 0, 3, 6, 9, 12, 15, 18 for hematological analysis. Results: DVA prolonged the nadir time for Hb, RBC, and WBC counts from day 9 to day 12 when compared to the carboplatin group. In terms of Platelet count, there was no significant difference over carboplatin. Group III showed a significant increase in Total reticulocyte count in comparison to group II. Conclusion: Present study showed that DVA may help in delaying the myelosuppression which needs further evaluation.http://www.sciencedirect.com/science/article/pii/S0975947622000584Dooshivishari AgadaCarboplatinMyelosuppression |
| spellingShingle | Santosh F. Patil Vishalaxi V. Shahapurkar Pukar Khanal Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats Journal of Ayurveda and Integrative Medicine Dooshivishari Agada Carboplatin Myelosuppression |
| title | Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats |
| title_full | Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats |
| title_fullStr | Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats |
| title_full_unstemmed | Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats |
| title_short | Effect of an Ayurveda antidote Dooshivishari Agada in carboplatin induced myelosuppression in Male Wistar rats |
| title_sort | effect of an ayurveda antidote dooshivishari agada in carboplatin induced myelosuppression in male wistar rats |
| topic | Dooshivishari Agada Carboplatin Myelosuppression |
| url | http://www.sciencedirect.com/science/article/pii/S0975947622000584 |
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