Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization
Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immedia...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2024-06-01
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| Series: | Carbohydrate Polymer Technologies and Applications |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666893924000185 |
| _version_ | 1797350559193235456 |
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| author | Jovana Petkovska Nikola Geskovski Darka Marković Vesna Dimova Dejan Mirakovski Maja Radetić Igor Jordanov |
| author_facet | Jovana Petkovska Nikola Geskovski Darka Marković Vesna Dimova Dejan Mirakovski Maja Radetić Igor Jordanov |
| author_sort | Jovana Petkovska |
| collection | DOAJ |
| description | Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH. |
| first_indexed | 2024-03-08T12:47:40Z |
| format | Article |
| id | doaj.art-b81c5a85a06545c68a15dff52e1c9526 |
| institution | Directory Open Access Journal |
| issn | 2666-8939 |
| language | English |
| last_indexed | 2024-03-08T12:47:40Z |
| publishDate | 2024-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Carbohydrate Polymer Technologies and Applications |
| spelling | doaj.art-b81c5a85a06545c68a15dff52e1c95262024-01-21T05:11:06ZengElsevierCarbohydrate Polymer Technologies and Applications2666-89392024-06-017100438Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterizationJovana Petkovska0Nikola Geskovski1Darka Marković2Vesna Dimova3Dejan Mirakovski4Maja Radetić5Igor Jordanov6Faculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje, Ruger Boskovic 16, Skopje 1000, North MacedoniaInstitute of Pharmaceutical Technology, Faculty of Pharmacy, University of Ss. Cyril and Methodius in Skopje, Majka Tereza 47, Skopje 1000, North MacedoniaInnovation Centre of the Faculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade 11120, SerbiaFaculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje, Ruger Boskovic 16, Skopje 1000, North MacedoniaFaculty of Natural and Technical Science, Goce Delcev University, Krste Misirkov 10-A, Shtip 2000, North MacedoniaFaculty of Technology and Metallurgy, University of Belgrade, Karnegijeva 4, Belgrade 11120, SerbiaFaculty of Technology and Metallurgy, Ss. Cyril and Methodius University in Skopje, Ruger Boskovic 16, Skopje 1000, North Macedonia; Corresponding author.Environmentally benign pH-indicating wound dressing comprised of carbohydrates chitosan (CH) and pectin (P), and anthocyanin grape (AG) dye is created via layer-by-layer assembly. Cotton fabric coated with eight bilayers of (CH-AG)4/(P-AG)4 deposited 1.97 % AG-dye. It exhibited a visible and immediate color change from pink to violet-blue while increasing its pH value from 6 to pH 7, matching the turning pH point of healing into an infected wound. Color transition of AG-dye in water-based buffers, tested by VIS-spectroscopy, shows the same color change when the pH value increased from 6 to 7. This coating imparts excellent antimicrobial activity against Gram-positive bacteria Staphylococcus aureus and yeast Candida albicans, moderate antibacterial activity against Gram-negative Escherichia coli bacteria, and no cytotoxicity on human fibroblast cells (MRC-5). This research proposes a sustainable, low-cost, and simple method for obtaining smart wound dressing that provides real-time monitoring of the wound pH.http://www.sciencedirect.com/science/article/pii/S2666893924000185Layer-by-layer coated cotton fabricSmart wound dressingAntimicrobial activityHumanfibroblast cellsAnthocyanin grape dyeAntifungal property |
| spellingShingle | Jovana Petkovska Nikola Geskovski Darka Marković Vesna Dimova Dejan Mirakovski Maja Radetić Igor Jordanov Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization Carbohydrate Polymer Technologies and Applications Layer-by-layer coated cotton fabric Smart wound dressing Antimicrobial activity Humanfibroblast cells Anthocyanin grape dye Antifungal property |
| title | Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization |
| title_full | Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization |
| title_fullStr | Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization |
| title_full_unstemmed | Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization |
| title_short | Chitosan-pectin multilayer coating with anthocyanin grape dye as pH indicating wound dressing: Synthesis and characterization |
| title_sort | chitosan pectin multilayer coating with anthocyanin grape dye as ph indicating wound dressing synthesis and characterization |
| topic | Layer-by-layer coated cotton fabric Smart wound dressing Antimicrobial activity Humanfibroblast cells Anthocyanin grape dye Antifungal property |
| url | http://www.sciencedirect.com/science/article/pii/S2666893924000185 |
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