MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia
Abstract Background MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor suppressive effects depending highly on the cellular context. The aim of t...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-03-01
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| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12967-018-1445-3 |
| _version_ | 1811204747701518336 |
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| author | Qiu-Ling Ma Jing-Han Wang Min Yang Huan-ping Wang Jie Jin |
| author_facet | Qiu-Ling Ma Jing-Han Wang Min Yang Huan-ping Wang Jie Jin |
| author_sort | Qiu-Ling Ma |
| collection | DOAJ |
| description | Abstract Background MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor suppressive effects depending highly on the cellular context. The aim of this study was to determine whether the expression of miR-362-5p can be served as a prognostic factor for patients with cytogentically normal acute myeloid leukemia (CN-AML). Methods We enrolled 224 patients with CN-AML and measured the expression of miR-362-5p by quantitative real time PCR analysis. We classified patients into high and low expression based on the median value. The Cox regression analyses were carried out to assess the prognostic significance of miR-362-5p expression in the context of the well-established predictors. Additionally, microRNA expression profiling were conducted to identify the biological insights between high and low group. Results High expressers had older age. High expressers obtained shorter overall survival in the univariate analysis. The independent prognostic value of miR-362-5p remained in the context of the well-established clinical and cytogenetic predictors. Moreover, the prognostic value of miR-362-5p was also validated in an independent cohort of CN-AML. Notably, numerous oncomiRs were also high expressed in high miR-362-5p group. Conclusion High miR-362-5p expression was associated with poorer overall survival implicating the oncogenic function in AML development. |
| first_indexed | 2024-04-12T03:18:55Z |
| format | Article |
| id | doaj.art-b81c98796ad649749d83611ed8748181 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-12T03:18:55Z |
| publishDate | 2018-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-b81c98796ad649749d83611ed87481812022-12-22T03:49:59ZengBMCJournal of Translational Medicine1479-58762018-03-011611610.1186/s12967-018-1445-3MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemiaQiu-Ling Ma0Jing-Han Wang1Min Yang2Huan-ping Wang3Jie Jin4Department of Hematology, The First Affiliated Hospital, Zhejiang University of MedicineDepartment of Hematology, The First Affiliated Hospital, Zhejiang University of MedicineDepartment of Hematology, The First Affiliated Hospital, Zhejiang University of MedicineKey Laboratory of Hematopoietic MalignanciesDepartment of Hematology, The First Affiliated Hospital, Zhejiang University of MedicineAbstract Background MicroRNAs are of special interest in cancer research and hold significant promise as diagnostic and prognostic biomarkers for malignant disease. MiR-362-5p have been found to exert both oncogenic and tumor suppressive effects depending highly on the cellular context. The aim of this study was to determine whether the expression of miR-362-5p can be served as a prognostic factor for patients with cytogentically normal acute myeloid leukemia (CN-AML). Methods We enrolled 224 patients with CN-AML and measured the expression of miR-362-5p by quantitative real time PCR analysis. We classified patients into high and low expression based on the median value. The Cox regression analyses were carried out to assess the prognostic significance of miR-362-5p expression in the context of the well-established predictors. Additionally, microRNA expression profiling were conducted to identify the biological insights between high and low group. Results High expressers had older age. High expressers obtained shorter overall survival in the univariate analysis. The independent prognostic value of miR-362-5p remained in the context of the well-established clinical and cytogenetic predictors. Moreover, the prognostic value of miR-362-5p was also validated in an independent cohort of CN-AML. Notably, numerous oncomiRs were also high expressed in high miR-362-5p group. Conclusion High miR-362-5p expression was associated with poorer overall survival implicating the oncogenic function in AML development.http://link.springer.com/article/10.1186/s12967-018-1445-3miR-362-5pAcute myeloid leukemiaGene expressionPrognosis |
| spellingShingle | Qiu-Ling Ma Jing-Han Wang Min Yang Huan-ping Wang Jie Jin MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia Journal of Translational Medicine miR-362-5p Acute myeloid leukemia Gene expression Prognosis |
| title | MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia |
| title_full | MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia |
| title_fullStr | MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia |
| title_full_unstemmed | MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia |
| title_short | MiR-362-5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia |
| title_sort | mir 362 5p as a novel prognostic predictor of cytogenetically normal acute myeloid leukemia |
| topic | miR-362-5p Acute myeloid leukemia Gene expression Prognosis |
| url | http://link.springer.com/article/10.1186/s12967-018-1445-3 |
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