Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis
Daniela A Moraes,1 Maria Carolina Oliveira2 1Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; 2Center for Cell-Based Therapy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazi...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2021-11-01
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| Series: | Journal of Blood Medicine |
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| Online Access: | https://www.dovepress.com/life-after-autologous-hematopoietic-stem-cell-transplantation-for-syst-peer-reviewed-fulltext-article-JBM |
| _version_ | 1818567458812854272 |
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| author | Moraes DA Oliveira MC |
| author_facet | Moraes DA Oliveira MC |
| author_sort | Moraes DA |
| collection | DOAJ |
| description | Daniela A Moraes,1 Maria Carolina Oliveira2 1Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; 2Center for Cell-Based Therapy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilCorrespondence: Maria Carolina OliveiraDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14048-900, BrazilEmail mcarolor@usp.brAbstract: Stem cell transplantation has been investigated as treatment for severe and progressive systemic sclerosis (SSc) for the past 25 years. To date, more than 1000 SSc patients have been transplanted worldwide. Overall and event-free survival have increased over the years, reflecting stricter patient selection criteria and better clinical management strategies. This review addresses long-term outcomes of transplanted SSc patients, considering phase I/II and randomized clinical trials, as well as observational studies and those assessing specific aspects of the disease. Clinical outcomes are discussed comparatively between studies, highlighting advances, drawbacks and controversies in the field. Areas for future development are also discussed.Keywords: systemic sclerosis, stem cell transplantation, long-term outcomes, progression-free survival |
| first_indexed | 2024-12-14T06:23:40Z |
| format | Article |
| id | doaj.art-b81e961720494f009ba5679a8878dfd4 |
| institution | Directory Open Access Journal |
| issn | 1179-2736 |
| language | English |
| last_indexed | 2024-12-14T06:23:40Z |
| publishDate | 2021-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Blood Medicine |
| spelling | doaj.art-b81e961720494f009ba5679a8878dfd42022-12-21T23:13:44ZengDove Medical PressJournal of Blood Medicine1179-27362021-11-01Volume 1295196470397Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic SclerosisMoraes DAOliveira MCDaniela A Moraes,1 Maria Carolina Oliveira2 1Division of Clinical Immunology, Department of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, Brazil; 2Center for Cell-Based Therapy, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, BrazilCorrespondence: Maria Carolina OliveiraDepartment of Internal Medicine, Ribeirão Preto Medical School, University of São Paulo, Avenida dos Bandeirantes, 3900, Ribeirão Preto, SP, 14048-900, BrazilEmail mcarolor@usp.brAbstract: Stem cell transplantation has been investigated as treatment for severe and progressive systemic sclerosis (SSc) for the past 25 years. To date, more than 1000 SSc patients have been transplanted worldwide. Overall and event-free survival have increased over the years, reflecting stricter patient selection criteria and better clinical management strategies. This review addresses long-term outcomes of transplanted SSc patients, considering phase I/II and randomized clinical trials, as well as observational studies and those assessing specific aspects of the disease. Clinical outcomes are discussed comparatively between studies, highlighting advances, drawbacks and controversies in the field. Areas for future development are also discussed.Keywords: systemic sclerosis, stem cell transplantation, long-term outcomes, progression-free survivalhttps://www.dovepress.com/life-after-autologous-hematopoietic-stem-cell-transplantation-for-syst-peer-reviewed-fulltext-article-JBMsystemic sclerosisstem cell transplantationlong-term outcomesprogression-free survival |
| spellingShingle | Moraes DA Oliveira MC Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis Journal of Blood Medicine systemic sclerosis stem cell transplantation long-term outcomes progression-free survival |
| title | Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis |
| title_full | Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis |
| title_fullStr | Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis |
| title_full_unstemmed | Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis |
| title_short | Life after Autologous Hematopoietic Stem Cell Transplantation for Systemic Sclerosis |
| title_sort | life after autologous hematopoietic stem cell transplantation for systemic sclerosis |
| topic | systemic sclerosis stem cell transplantation long-term outcomes progression-free survival |
| url | https://www.dovepress.com/life-after-autologous-hematopoietic-stem-cell-transplantation-for-syst-peer-reviewed-fulltext-article-JBM |
| work_keys_str_mv | AT moraesda lifeafterautologoushematopoieticstemcelltransplantationforsystemicsclerosis AT oliveiramc lifeafterautologoushematopoieticstemcelltransplantationforsystemicsclerosis |