Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients
Background and Aims: The preponderance of microscopic colitis (MC) in females may be associated with postmenopausal increased risk of atherosclerosis. The aim of this study was to describe the prevalence of atherosclerotic diseases in adults with MC. Methods: Retrospective observational study of pat...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Gastro Hep Advances |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2772572323001012 |
| _version_ | 1827791680316637184 |
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| author | Paul Hong Karolina Krawczyk Rehmat U. Awan Raza Hasan Poornima Oruganti Xianzhong Ding Michael Wesolowski Ayokunle T. Abegunde |
| author_facet | Paul Hong Karolina Krawczyk Rehmat U. Awan Raza Hasan Poornima Oruganti Xianzhong Ding Michael Wesolowski Ayokunle T. Abegunde |
| author_sort | Paul Hong |
| collection | DOAJ |
| description | Background and Aims: The preponderance of microscopic colitis (MC) in females may be associated with postmenopausal increased risk of atherosclerosis. The aim of this study was to describe the prevalence of atherosclerotic diseases in adults with MC. Methods: Retrospective observational study of patients with a diagnosis of MC or incomplete MC at our institution from 2008 to 2018. We performed a chart review and extracted data on demographics, comorbidities, medications, diagnosis, imaging, and endoscopy. Data were analyzed descriptively. Logistic regression was used to estimate the unadjusted effects of different variables on MC. Results: Of 269 patients, 265 had a MC diagnosis; 236 (89.06%) had collagenous colitis or lymphocytic colitis; and 29 (10.94%) were diagnosed with incomplete MC. Majority were female (79.55%), ≥ 65 years (59.11%), and white (88.81%). Majority had the following risk factors for atherosclerosis, smoking (52.04%), hypertension (58.21%), and hyperlipidemia (59.5%). The prevalence of coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease (CVD) was 16.79% (12.32, 21.27), 8.58% (5.23–11.94), and 7.49% (4.33–10.65), respectively. There was no difference in the prevalence of CAD and CVD after adjusting for sex. Females with MC had reduced odds of PAD compared with males. Conclusion: The prevalence of CAD, PAD, and CVD was 16.79%, 8.58%, and 7.49%, respectively. Similar to the general population, smoking, hypertension, and hyperlipidemia are risk factors for atherosclerosis in MC. |
| first_indexed | 2024-03-11T17:51:16Z |
| format | Article |
| id | doaj.art-b81ef50db8c04fb2bee03174a2c1dea0 |
| institution | Directory Open Access Journal |
| issn | 2772-5723 |
| language | English |
| last_indexed | 2024-03-11T17:51:16Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Gastro Hep Advances |
| spelling | doaj.art-b81ef50db8c04fb2bee03174a2c1dea02023-10-18T04:31:51ZengElsevierGastro Hep Advances2772-57232023-01-0127971978Prevalence of Atherosclerotic Disease in Microscopic Colitis PatientsPaul Hong0Karolina Krawczyk1Rehmat U. Awan2Raza Hasan3Poornima Oruganti4Xianzhong Ding5Michael Wesolowski6Ayokunle T. Abegunde7Department of Internal Medicine, Loyola University Medical Center, Maywood, IllinoisDepartment of Internal Medicine, Loyola University Medical Center, Maywood, IllinoisDepartment of Internal Medicine, Loyola University Medical Center, Maywood, IllinoisDivision of Gastroenterology and Nutrition, Loyola University Medical Center, Maywood, IllinoisDepartment of Internal Medicine, Loyola University Medical Center, Maywood, IllinoisDepartment of Pathology, Loyola University Medical Center, Maywood, IllinoisLoyola University Chicago, Clinical Research Office Biostatistics Collaborative Core, Chicago, IllinoisDivision of Gastroenterology and Nutrition, Loyola University Medical Center, Maywood, Illinois; Correspondence: Address correspondence to: Ayokunle T. Abegunde, MD, MSc, MRCGP, FACP, FACG, Division of Gastroenterology and Nutrition, Loyola University Medical Center, Maywood, Illinois.Background and Aims: The preponderance of microscopic colitis (MC) in females may be associated with postmenopausal increased risk of atherosclerosis. The aim of this study was to describe the prevalence of atherosclerotic diseases in adults with MC. Methods: Retrospective observational study of patients with a diagnosis of MC or incomplete MC at our institution from 2008 to 2018. We performed a chart review and extracted data on demographics, comorbidities, medications, diagnosis, imaging, and endoscopy. Data were analyzed descriptively. Logistic regression was used to estimate the unadjusted effects of different variables on MC. Results: Of 269 patients, 265 had a MC diagnosis; 236 (89.06%) had collagenous colitis or lymphocytic colitis; and 29 (10.94%) were diagnosed with incomplete MC. Majority were female (79.55%), ≥ 65 years (59.11%), and white (88.81%). Majority had the following risk factors for atherosclerosis, smoking (52.04%), hypertension (58.21%), and hyperlipidemia (59.5%). The prevalence of coronary artery disease (CAD), peripheral artery disease (PAD), and cerebrovascular disease (CVD) was 16.79% (12.32, 21.27), 8.58% (5.23–11.94), and 7.49% (4.33–10.65), respectively. There was no difference in the prevalence of CAD and CVD after adjusting for sex. Females with MC had reduced odds of PAD compared with males. Conclusion: The prevalence of CAD, PAD, and CVD was 16.79%, 8.58%, and 7.49%, respectively. Similar to the general population, smoking, hypertension, and hyperlipidemia are risk factors for atherosclerosis in MC.http://www.sciencedirect.com/science/article/pii/S2772572323001012PrevalenceAtherosclerosisMicroscopicColitis |
| spellingShingle | Paul Hong Karolina Krawczyk Rehmat U. Awan Raza Hasan Poornima Oruganti Xianzhong Ding Michael Wesolowski Ayokunle T. Abegunde Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients Gastro Hep Advances Prevalence Atherosclerosis Microscopic Colitis |
| title | Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients |
| title_full | Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients |
| title_fullStr | Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients |
| title_full_unstemmed | Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients |
| title_short | Prevalence of Atherosclerotic Disease in Microscopic Colitis Patients |
| title_sort | prevalence of atherosclerotic disease in microscopic colitis patients |
| topic | Prevalence Atherosclerosis Microscopic Colitis |
| url | http://www.sciencedirect.com/science/article/pii/S2772572323001012 |
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