Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

Pharmacological rescue of specific long QT variants of KCNQ1/KCNE1 channels

The congenital Long QT Syndrome (LQTS) is an inherited disorder in which cardiac ventricular repolarization is delayed and predisposes patients to cardiac arrhythmias and sudden cardiac death. LQT1 and LQT5 are LQTS variants caused by mutations in KCNQ1 or KCNE1 genes respectively. KCNQ1 and KCNE1 c...

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Bibliographic Details
Main Authors: Xinle Zou, Xiaoan Wu, Kevin J. Sampson, Henry M. Colecraft, H. Peter Larsson, Robert S. Kass
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Physiology
Subjects:
long QT syndrome
IKS
potassium channel
pharmacology
KCNQ1
KCNE1
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2022.902224/full

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