The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections
Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activat...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-06-01
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| Series: | Pharmaceuticals |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1424-8247/15/6/767 |
| _version_ | 1797483422107566080 |
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| author | Shima Afrasiabi Alireza Partoazar Nasim Chiniforush Ramin Goudarzi |
| author_facet | Shima Afrasiabi Alireza Partoazar Nasim Chiniforush Ramin Goudarzi |
| author_sort | Shima Afrasiabi |
| collection | DOAJ |
| description | Oral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, <i>chlorella</i>, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections. |
| first_indexed | 2024-03-09T22:46:45Z |
| format | Article |
| id | doaj.art-b8227edc7c004fe895b13eaa565a2097 |
| institution | Directory Open Access Journal |
| issn | 1424-8247 |
| language | English |
| last_indexed | 2024-03-09T22:46:45Z |
| publishDate | 2022-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pharmaceuticals |
| spelling | doaj.art-b8227edc7c004fe895b13eaa565a20972023-11-23T18:28:23ZengMDPI AGPharmaceuticals1424-82472022-06-0115676710.3390/ph15060767The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral InfectionsShima Afrasiabi0Alireza Partoazar1Nasim Chiniforush2Ramin Goudarzi3Laser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, IranExperimental Medicine Research Center, Tehran University of Medical Sciences, Tehran 1441987566, IranLaser Research Center of Dentistry, Dentistry Research Institute, Tehran University of Medical Sciences, Tehran 1441987566, IranDivision of Research and Development, Pharmin USA, LLC, San Jose, CA 95128, USAOral health problems and the emergence of antimicrobial resistance among pathogenic bacterial strains have become major global challenges and are essential elements that negatively affect general well-being. Antimicrobial photodynamic therapy (APDT) is based on a light source and oxygen that activates a nontoxic photosensitizer, resulting in microbial destruction. Synthetic and natural products can be used to help the APDT against oral microorganisms. The undesirable consequences of conventional photosensitizers, including toxicity, and cost encourage researchers to explore new promising photosensitizers based on natural compounds such as curcumin, <i>chlorella</i>, chlorophyllin, phycocyanin, 5-aminolevulinic acid, and riboflavin. In this review, we summarize in vitro studies describing the potential use of APDT therapy conjugated with some natural products against selected microorganisms that are considered to be responsible for oral infections.https://www.mdpi.com/1424-8247/15/6/767photosensitizing agentsphotochemotherapydental infection controldrug resistancebiofilmsnanoparticles |
| spellingShingle | Shima Afrasiabi Alireza Partoazar Nasim Chiniforush Ramin Goudarzi The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections Pharmaceuticals photosensitizing agents photochemotherapy dental infection control drug resistance biofilms nanoparticles |
| title | The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections |
| title_full | The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections |
| title_fullStr | The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections |
| title_full_unstemmed | The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections |
| title_short | The Potential Application of Natural Photosensitizers Used in Antimicrobial Photodynamic Therapy against Oral Infections |
| title_sort | potential application of natural photosensitizers used in antimicrobial photodynamic therapy against oral infections |
| topic | photosensitizing agents photochemotherapy dental infection control drug resistance biofilms nanoparticles |
| url | https://www.mdpi.com/1424-8247/15/6/767 |
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