Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis)
Four mongrel dogs were intradermically inoculated with 3 x 10**6 Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was...
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
1988-06-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761988000200001 |
| _version_ | 1827833102140964864 |
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| author | Claude Pirmez Mauro C. A. Marzochi Sergio G. Coutinho |
| author_facet | Claude Pirmez Mauro C. A. Marzochi Sergio G. Coutinho |
| author_sort | Claude Pirmez |
| collection | DOAJ |
| description | Four mongrel dogs were intradermically inoculated with 3 x 10**6 Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was seen 16 months after the inoculum. Clinical, histopathological, and serological findings were similar to what is found in natural canine infection as well as in the human disease. These results suggest that dogs may be an useful model for L. b. braziliensis infection.<br>Quatro cães foram inoculados por via intredérmica com 3 x 10**6 promastigotos de Leishmania brasiliensis braziliensis. Três deles desenvolveram lesões no sítio do inóculo, mas uma úlcera mucosa foi detectada 16 meses após o inóculo. Os achados foram similares áqueles verificados na infecção canina natural, bem como na doença humana. Estes resultados sugerem que o cão pode representar um modelo experimental para a infecção causada pela L. b. brasiliensis. |
| first_indexed | 2024-03-12T05:24:03Z |
| format | Article |
| id | doaj.art-b823e749d5dd408fbb8f0b666f21b499 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T05:24:03Z |
| publishDate | 1988-06-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-b823e749d5dd408fbb8f0b666f21b4992023-09-03T07:27:16ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80601988-06-0183214515110.1590/S0074-02761988000200001Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis)Claude PirmezMauro C. A. MarzochiSergio G. CoutinhoFour mongrel dogs were intradermically inoculated with 3 x 10**6 Leishmania braziliensis braziliensis promastigotes. Three out of the four animals developed cutaneous lesions respectively 4, 7, and 8 months after. The fourth dog did not develop lesion at the inoculation site, but a mucosal ulcer was seen 16 months after the inoculum. Clinical, histopathological, and serological findings were similar to what is found in natural canine infection as well as in the human disease. These results suggest that dogs may be an useful model for L. b. braziliensis infection.<br>Quatro cães foram inoculados por via intredérmica com 3 x 10**6 promastigotos de Leishmania brasiliensis braziliensis. Três deles desenvolveram lesões no sítio do inóculo, mas uma úlcera mucosa foi detectada 16 meses após o inóculo. Os achados foram similares áqueles verificados na infecção canina natural, bem como na doença humana. Estes resultados sugerem que o cão pode representar um modelo experimental para a infecção causada pela L. b. brasiliensis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761988000200001Leishmania braziliensis braziliensisinfecção canina experimentalLeishmania braziliensis braziliensiscanine experimental infection |
| spellingShingle | Claude Pirmez Mauro C. A. Marzochi Sergio G. Coutinho Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis) Memorias do Instituto Oswaldo Cruz Leishmania braziliensis braziliensis infecção canina experimental Leishmania braziliensis braziliensis canine experimental infection |
| title | Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis) |
| title_full | Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis) |
| title_fullStr | Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis) |
| title_full_unstemmed | Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis) |
| title_short | Experimental canine mucocutaneous leishmaniasis (Leishmania braziliensis braziliensis) |
| title_sort | experimental canine mucocutaneous leishmaniasis leishmania braziliensis braziliensis |
| topic | Leishmania braziliensis braziliensis infecção canina experimental Leishmania braziliensis braziliensis canine experimental infection |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02761988000200001 |
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