Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants
The aim of the present study was to investigate the polyphenolic profile and the anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso: <i>Parkia biglobosa</i>, <i>Detarium microcarpum</i>, <i>Vitellaria paradoxa...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/11/10/1377 |
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| author | Windmi Kagambega Hadidjatou Belem Roland Nâg-Tiéro Meda Benjamin Kouliga Koama Anne-Flora Drabo Jacques Kabore Amadou Traore Georges Anicet Ouédraogo Daniela Benedec Daniela Hanganu Laurian Vlase Ana-Maria Vlase Oliviu Voștinaru Cristina Mogoșan Ilioara Oniga |
| author_facet | Windmi Kagambega Hadidjatou Belem Roland Nâg-Tiéro Meda Benjamin Kouliga Koama Anne-Flora Drabo Jacques Kabore Amadou Traore Georges Anicet Ouédraogo Daniela Benedec Daniela Hanganu Laurian Vlase Ana-Maria Vlase Oliviu Voștinaru Cristina Mogoșan Ilioara Oniga |
| author_sort | Windmi Kagambega |
| collection | DOAJ |
| description | The aim of the present study was to investigate the polyphenolic profile and the anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso: <i>Parkia biglobosa</i>, <i>Detarium microcarpum</i>, <i>Vitellaria paradoxa</i> and <i>Sclerocarya birrea</i>. The analysis of the main phenolic compounds was performed by the HPLC-UV-MS method. The anti-inflammatory effect of the aqueous bark extracts was investigated by the λ-carrageenan-induced rat paw edema test. The anti-nociceptive activity was evaluated by the Randall–Selitto test under inflammatory conditions. Seven phenolic acids (gallic, protocatechuic, gentisic, vanillic, <i>p</i>-coumaric, ferulic, and syringic acids), and three flavonoids (catechin, epicatechin, and quercitrin) were identified in the plant samples. High contents of gallic acid were determined in the <i>D. microcarpum</i>, <i>P. biglobosa</i> and <i>S. birrea</i> extracts (190–300 mg/100 g), and <i>V. paradoxa</i> extract was the richest in epicatechin (173.86 mg/100 g). The <i>λ</i>-carrageenan-induced inflammation was significantly reduced (<i>p</i> < 0.001) by the <i>P. biglobosa</i> and <i>D. microcarpum</i> extracts (400 mg/kg p.o.). Under the inflammatory conditions, a significant anti-nociceptive activity (<i>p</i> < 0.001) was obtained after 2–3 h from the induction of inflammation. The effects of the tested extracts could be related to the presence of polyphenols and could be useful in the management of certain inflammatory diseases. |
| first_indexed | 2024-03-10T03:03:02Z |
| format | Article |
| id | doaj.art-b824eb1934b246a2a0c7cf78af3b298a |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T03:03:02Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-b824eb1934b246a2a0c7cf78af3b298a2023-11-23T12:43:45ZengMDPI AGPlants2223-77472022-05-011110137710.3390/plants11101377Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal PlantsWindmi Kagambega0Hadidjatou Belem1Roland Nâg-Tiéro Meda2Benjamin Kouliga Koama3Anne-Flora Drabo4Jacques Kabore5Amadou Traore6Georges Anicet Ouédraogo7Daniela Benedec8Daniela Hanganu9Laurian Vlase10Ana-Maria Vlase11Oliviu Voștinaru12Cristina Mogoșan13Ilioara Oniga14Laboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité De Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoLaboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité De Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoLaboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité De Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoLaboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité De Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoLaboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité De Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoUnité de Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoLaboratoire de Biologie et Santé Animales, Institut de l’Environnement et de Recherches Agricoles (INERA), Ouagadougou 04 BP 8645, Burkina FasoLaboratoire de Recherche et d’Enseignement en Santé et Biotechnologies Animales, Unité De Formation et de Recherche en Sciences et Techniques, Université Nazi Boni, Bobo-Dioulasso 01 BP 1091, Burkina FasoFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaFaculty of Pharmacy, “Iuliu Hatieganu” University of Medicine and Pharmacy, 8 V. Babes Street, 400010 Cluj-Napoca, RomaniaThe aim of the present study was to investigate the polyphenolic profile and the anti-inflammatory and anti-nociceptive activities of four traditionally used medicinal plants from Burkina Faso: <i>Parkia biglobosa</i>, <i>Detarium microcarpum</i>, <i>Vitellaria paradoxa</i> and <i>Sclerocarya birrea</i>. The analysis of the main phenolic compounds was performed by the HPLC-UV-MS method. The anti-inflammatory effect of the aqueous bark extracts was investigated by the λ-carrageenan-induced rat paw edema test. The anti-nociceptive activity was evaluated by the Randall–Selitto test under inflammatory conditions. Seven phenolic acids (gallic, protocatechuic, gentisic, vanillic, <i>p</i>-coumaric, ferulic, and syringic acids), and three flavonoids (catechin, epicatechin, and quercitrin) were identified in the plant samples. High contents of gallic acid were determined in the <i>D. microcarpum</i>, <i>P. biglobosa</i> and <i>S. birrea</i> extracts (190–300 mg/100 g), and <i>V. paradoxa</i> extract was the richest in epicatechin (173.86 mg/100 g). The <i>λ</i>-carrageenan-induced inflammation was significantly reduced (<i>p</i> < 0.001) by the <i>P. biglobosa</i> and <i>D. microcarpum</i> extracts (400 mg/kg p.o.). Under the inflammatory conditions, a significant anti-nociceptive activity (<i>p</i> < 0.001) was obtained after 2–3 h from the induction of inflammation. The effects of the tested extracts could be related to the presence of polyphenols and could be useful in the management of certain inflammatory diseases.https://www.mdpi.com/2223-7747/11/10/1377<i>Parkia biglobosa</i><i>Detarium microcarpum</i><i>Vitellaria paradoxa</i><i>Sclerocarya birrea</i>polyphenolsanti-inflammatory |
| spellingShingle | Windmi Kagambega Hadidjatou Belem Roland Nâg-Tiéro Meda Benjamin Kouliga Koama Anne-Flora Drabo Jacques Kabore Amadou Traore Georges Anicet Ouédraogo Daniela Benedec Daniela Hanganu Laurian Vlase Ana-Maria Vlase Oliviu Voștinaru Cristina Mogoșan Ilioara Oniga Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants Plants <i>Parkia biglobosa</i> <i>Detarium microcarpum</i> <i>Vitellaria paradoxa</i> <i>Sclerocarya birrea</i> polyphenols anti-inflammatory |
| title | Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants |
| title_full | Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants |
| title_fullStr | Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants |
| title_full_unstemmed | Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants |
| title_short | Polyphenolic Profile, Anti-Inflammatory and Anti-Nociceptive Activities of Some African Medicinal Plants |
| title_sort | polyphenolic profile anti inflammatory and anti nociceptive activities of some african medicinal plants |
| topic | <i>Parkia biglobosa</i> <i>Detarium microcarpum</i> <i>Vitellaria paradoxa</i> <i>Sclerocarya birrea</i> polyphenols anti-inflammatory |
| url | https://www.mdpi.com/2223-7747/11/10/1377 |
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