Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy
In order to solve COVID-19 pandemic, the entire world has invested considerable manpower to develop various new vaccines to temporarily alleviate the disaster caused by the epidemic. In addition to the development of vaccines, we need to also develop effective assessment methods to confirm vaccines’...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-10-01
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| Series: | Vaccines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2076-393X/10/10/1681 |
| _version_ | 1797469718351708160 |
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| author | Yen-Pin Lin Yi-Shan Hsieh Mei-Hsiu Cheng Ching-Fen Shen Ching-Ju Shen Chao-Min Cheng |
| author_facet | Yen-Pin Lin Yi-Shan Hsieh Mei-Hsiu Cheng Ching-Fen Shen Ching-Ju Shen Chao-Min Cheng |
| author_sort | Yen-Pin Lin |
| collection | DOAJ |
| description | In order to solve COVID-19 pandemic, the entire world has invested considerable manpower to develop various new vaccines to temporarily alleviate the disaster caused by the epidemic. In addition to the development of vaccines, we need to also develop effective assessment methods to confirm vaccines’ efficacy and maximize the benefits that vaccines can bring. In addition to common evaluation methods, vaccine-specific and temporal expression of microRNAs have been shown to be related to vaccine efficacy or vaccine-associated diseases. In this article, we have introduced a microRNA-array-based approach, which could be potentially used for evaluating COVID-19 vaccine efficacy, specifically for pregnant women. As the mRNA in mRNA vaccines is decomposed by host cells within a few days, it is considered more suitable for pregnant women to utilize the method of vaccination during pregnancy. Moreover, pregnant women belong to a high-risk group for COVID-19, and there is currently no appropriate vaccine to newborns. Therefore, it’s important to find improved tools for evaluation of vaccine efficacy in response to the current situation caused by COVID-19. |
| first_indexed | 2024-03-09T19:24:15Z |
| format | Article |
| id | doaj.art-b826ce669ae84d16914585f0bd14d23d |
| institution | Directory Open Access Journal |
| issn | 2076-393X |
| language | English |
| last_indexed | 2024-03-09T19:24:15Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Vaccines |
| spelling | doaj.art-b826ce669ae84d16914585f0bd14d23d2023-11-24T03:04:11ZengMDPI AGVaccines2076-393X2022-10-011010168110.3390/vaccines10101681Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine EfficacyYen-Pin Lin0Yi-Shan Hsieh1Mei-Hsiu Cheng2Ching-Fen Shen3Ching-Ju Shen4Chao-Min Cheng5Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, TaiwanTaiwan Business Development Department, Inti Taiwan, Inc., Hsinchu 302, TaiwanTaiwan Business Development Department, Inti Taiwan, Inc., Hsinchu 302, TaiwanDepartment of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, TaiwanDepartment of Obstetrics and Gynecology, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 807, TaiwanInstitute of Biomedical Engineering, National Tsing Hua University, Hsinchu 300, TaiwanIn order to solve COVID-19 pandemic, the entire world has invested considerable manpower to develop various new vaccines to temporarily alleviate the disaster caused by the epidemic. In addition to the development of vaccines, we need to also develop effective assessment methods to confirm vaccines’ efficacy and maximize the benefits that vaccines can bring. In addition to common evaluation methods, vaccine-specific and temporal expression of microRNAs have been shown to be related to vaccine efficacy or vaccine-associated diseases. In this article, we have introduced a microRNA-array-based approach, which could be potentially used for evaluating COVID-19 vaccine efficacy, specifically for pregnant women. As the mRNA in mRNA vaccines is decomposed by host cells within a few days, it is considered more suitable for pregnant women to utilize the method of vaccination during pregnancy. Moreover, pregnant women belong to a high-risk group for COVID-19, and there is currently no appropriate vaccine to newborns. Therefore, it’s important to find improved tools for evaluation of vaccine efficacy in response to the current situation caused by COVID-19.https://www.mdpi.com/2076-393X/10/10/1681microRNA arrayCOVID-19mRNA vaccinepregnancyimmune response |
| spellingShingle | Yen-Pin Lin Yi-Shan Hsieh Mei-Hsiu Cheng Ching-Fen Shen Ching-Ju Shen Chao-Min Cheng Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy Vaccines microRNA array COVID-19 mRNA vaccine pregnancy immune response |
| title | Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy |
| title_full | Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy |
| title_fullStr | Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy |
| title_full_unstemmed | Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy |
| title_short | Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy |
| title_sort | using microrna arrays as a tool to evaluate covid 19 vaccine efficacy |
| topic | microRNA array COVID-19 mRNA vaccine pregnancy immune response |
| url | https://www.mdpi.com/2076-393X/10/10/1681 |
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