Gastric leiomyosarcoma in a 3-year-old boy
A 3-year-old boy presented with anemia and a palpable abdominal tumor. The operative finding was a 10.5×9.6×4.6-cm tumor that infiltrated the anterior wall of the stomach. Local excision was performed. The tumor was histopathologically diagnosed as leiomyosarcoma with immunoreactivity for alpha-smoo...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2019-11-01
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| Series: | Journal of Pediatric Surgery Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213576619300569 |
| _version_ | 1818897904424714240 |
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| author | Naruo Tokuyasu Suichi Takano Norio Shimizu Joji Watanabe Takehiko Hanaki Masaki Morimoto Ei Uchinaka Takuki Yagyu Teruhisa Sakamoto Soichiro Honjo Takako Yoshioka Yoshiyuki Fujiwara |
| author_facet | Naruo Tokuyasu Suichi Takano Norio Shimizu Joji Watanabe Takehiko Hanaki Masaki Morimoto Ei Uchinaka Takuki Yagyu Teruhisa Sakamoto Soichiro Honjo Takako Yoshioka Yoshiyuki Fujiwara |
| author_sort | Naruo Tokuyasu |
| collection | DOAJ |
| description | A 3-year-old boy presented with anemia and a palpable abdominal tumor. The operative finding was a 10.5×9.6×4.6-cm tumor that infiltrated the anterior wall of the stomach. Local excision was performed. The tumor was histopathologically diagnosed as leiomyosarcoma with immunoreactivity for alpha-smooth muscle actin and muscle actin, but not for CD34, c-kit, and S-100. The tumor was characterized as highly malignant because of its size, high mitotic count, nuclear atypia, and high MIB-1 labeling index. After 6 months of follow-up, recurrence developed in the remnant stomach and liver metastasis was observed. Partial gastrectomy and lateral segment resection of the liver were performed. Subsequently, multiple recurrences in the remnant liver and peritoneal dissemination occurred. The patient underwent follow-up without adjuvant therapy and was well for more than 10 years after liver metastases and peritoneal dissemination after the initial surgery. This case represents the different biological behavior of pediatric gastrointestinal leiomyosarcoma compared to adult gastrointestinal leiomyosarcoma. Keywords: Leiomyosarcoma, Pediatric, Prognosis, Metastasis, Surgery |
| first_indexed | 2024-12-19T19:23:35Z |
| format | Article |
| id | doaj.art-b828a02a6440489ca449d900b487837f |
| institution | Directory Open Access Journal |
| issn | 2213-5766 |
| language | English |
| last_indexed | 2024-12-19T19:23:35Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pediatric Surgery Case Reports |
| spelling | doaj.art-b828a02a6440489ca449d900b487837f2022-12-21T20:08:54ZengElsevierJournal of Pediatric Surgery Case Reports2213-57662019-11-0150Gastric leiomyosarcoma in a 3-year-old boyNaruo Tokuyasu0Suichi Takano1Norio Shimizu2Joji Watanabe3Takehiko Hanaki4Masaki Morimoto5Ei Uchinaka6Takuki Yagyu7Teruhisa Sakamoto8Soichiro Honjo9Takako Yoshioka10Yoshiyuki Fujiwara11Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, Japan; Corresponding author. Division of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, 86 Nishi-cho, Yonago, 683-8503, Japan.Division of Predict Surgery, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Predict Surgery, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanDivision of Pathology, National Center for Child Health and Development, Tokyo, JapanDivision of Surgical Oncology, Department of Surgery, Faculty of Medicine, Tottori University, Yonago, JapanA 3-year-old boy presented with anemia and a palpable abdominal tumor. The operative finding was a 10.5×9.6×4.6-cm tumor that infiltrated the anterior wall of the stomach. Local excision was performed. The tumor was histopathologically diagnosed as leiomyosarcoma with immunoreactivity for alpha-smooth muscle actin and muscle actin, but not for CD34, c-kit, and S-100. The tumor was characterized as highly malignant because of its size, high mitotic count, nuclear atypia, and high MIB-1 labeling index. After 6 months of follow-up, recurrence developed in the remnant stomach and liver metastasis was observed. Partial gastrectomy and lateral segment resection of the liver were performed. Subsequently, multiple recurrences in the remnant liver and peritoneal dissemination occurred. The patient underwent follow-up without adjuvant therapy and was well for more than 10 years after liver metastases and peritoneal dissemination after the initial surgery. This case represents the different biological behavior of pediatric gastrointestinal leiomyosarcoma compared to adult gastrointestinal leiomyosarcoma. Keywords: Leiomyosarcoma, Pediatric, Prognosis, Metastasis, Surgeryhttp://www.sciencedirect.com/science/article/pii/S2213576619300569 |
| spellingShingle | Naruo Tokuyasu Suichi Takano Norio Shimizu Joji Watanabe Takehiko Hanaki Masaki Morimoto Ei Uchinaka Takuki Yagyu Teruhisa Sakamoto Soichiro Honjo Takako Yoshioka Yoshiyuki Fujiwara Gastric leiomyosarcoma in a 3-year-old boy Journal of Pediatric Surgery Case Reports |
| title | Gastric leiomyosarcoma in a 3-year-old boy |
| title_full | Gastric leiomyosarcoma in a 3-year-old boy |
| title_fullStr | Gastric leiomyosarcoma in a 3-year-old boy |
| title_full_unstemmed | Gastric leiomyosarcoma in a 3-year-old boy |
| title_short | Gastric leiomyosarcoma in a 3-year-old boy |
| title_sort | gastric leiomyosarcoma in a 3 year old boy |
| url | http://www.sciencedirect.com/science/article/pii/S2213576619300569 |
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