ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE
Objective of research: to study the efficacy of supramolecular complexes of Phenasalum at monieziasis in cattle.Materials and methods: After helminthoovoscopic examination of feces by Fülleborn’s flotation method and evaluation of extensity and intensity of invasion, we have selected and formed acco...
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| Format: | Article |
| Language: | Russian |
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Federal Scientific Centre VIEV
2016-12-01
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| Series: | Российский паразитологический журнал |
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| Online Access: | https://vniigis.elpub.ru/jour/article/view/347 |
| _version_ | 1797270512189046784 |
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| author | Yu. V. Limova K. M. Sadov S. G. Kanatbaev I. A. Arkhipov |
| author_facet | Yu. V. Limova K. M. Sadov S. G. Kanatbaev I. A. Arkhipov |
| author_sort | Yu. V. Limova |
| collection | DOAJ |
| description | Objective of research: to study the efficacy of supramolecular complexes of Phenasalum at monieziasis in cattle.Materials and methods: After helminthoovoscopic examination of feces by Fülleborn’s flotation method and evaluation of extensity and intensity of invasion, we have selected and formed according to the principle of analogs, 5 groups (10 heads each) of Kazakh white-headed calves at the age of 6–7 mo. Animals in experimental groups received drugs orally as a single dose. Calves of the first group received a supramolecular complex of Phenasalum with Polyvinylpyrrolidone (PVP) in the ratio 1 : 2 at a dose of 20 mg a.i./kg (60 mg/kg of the body mass). The second group of animals was given a complex of Phenasalum with Arabinogalactan (AG) in the ratio 1: 2 at a dose of 20 mg a.i./kg (60 mg/kg of the body mass). Calves of the third group received a complex of Phenasalum with SiO2 in the ratio 1: 5 at a dose of 20 mg a.i./kg. Animals of the fourth group complex of Phenasalum with Arabinogalactan (AG) in the ratio 1:5 at a dose of 20 mg a.i./kg and 120 mg/kg of the body mass. Animal of the fifth group didn’t receive anthelmintics and served as controls. 14 days after giving the tested drugs, fecal samples were collected from all animal groups and helminthoovoscopic examinations were carried out.Results and discussion: The experiment showed that at the supramolecular complexes of Phenasalum with Polyvinylpyrrolidone (PVP) in the ratio 1 : 2 and Phenasalum with Arabinogalactan (AG) in the ratio 1 : 2 at a dose of 20 mg a.i./kg were the most effective at monieziasis in cattle. The efficacy of the complex of Phenasalum with SiO2 in the ratio 1: 5 was 74 %. The doses of tested drugs (20 mg a.i./kg) were 5 times less than that of the based Phenasalum (100 mg/kg). |
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| format | Article |
| id | doaj.art-b82a5cae4d394fb18095cf0357ac3de8 |
| institution | Directory Open Access Journal |
| issn | 1998-8435 2541-7843 |
| language | Russian |
| last_indexed | 2024-04-25T02:05:27Z |
| publishDate | 2016-12-01 |
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| series | Российский паразитологический журнал |
| spelling | doaj.art-b82a5cae4d394fb18095cf0357ac3de82024-03-07T14:34:29ZrusFederal Scientific Centre VIEVРоссийский паразитологический журнал1998-84352541-78432016-12-0136222322710.12737/20066347ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLEYu. V. Limova0K. M. Sadov1S. G. Kanatbaev2I. A. Arkhipov3Samara Research Veterinary StationSamara Research Veterinary StationWest Kazakhstan Research Veterinary StationAll-Russian Scientific Research Institute of Fundamental and Applied Parasitology of Animals and Plants named after K.I. SkryabinObjective of research: to study the efficacy of supramolecular complexes of Phenasalum at monieziasis in cattle.Materials and methods: After helminthoovoscopic examination of feces by Fülleborn’s flotation method and evaluation of extensity and intensity of invasion, we have selected and formed according to the principle of analogs, 5 groups (10 heads each) of Kazakh white-headed calves at the age of 6–7 mo. Animals in experimental groups received drugs orally as a single dose. Calves of the first group received a supramolecular complex of Phenasalum with Polyvinylpyrrolidone (PVP) in the ratio 1 : 2 at a dose of 20 mg a.i./kg (60 mg/kg of the body mass). The second group of animals was given a complex of Phenasalum with Arabinogalactan (AG) in the ratio 1: 2 at a dose of 20 mg a.i./kg (60 mg/kg of the body mass). Calves of the third group received a complex of Phenasalum with SiO2 in the ratio 1: 5 at a dose of 20 mg a.i./kg. Animals of the fourth group complex of Phenasalum with Arabinogalactan (AG) in the ratio 1:5 at a dose of 20 mg a.i./kg and 120 mg/kg of the body mass. Animal of the fifth group didn’t receive anthelmintics and served as controls. 14 days after giving the tested drugs, fecal samples were collected from all animal groups and helminthoovoscopic examinations were carried out.Results and discussion: The experiment showed that at the supramolecular complexes of Phenasalum with Polyvinylpyrrolidone (PVP) in the ratio 1 : 2 and Phenasalum with Arabinogalactan (AG) in the ratio 1 : 2 at a dose of 20 mg a.i./kg were the most effective at monieziasis in cattle. The efficacy of the complex of Phenasalum with SiO2 in the ratio 1: 5 was 74 %. The doses of tested drugs (20 mg a.i./kg) were 5 times less than that of the based Phenasalum (100 mg/kg).https://vniigis.elpub.ru/jour/article/view/347supramolecular complexphenasalumcalveshelminthiasishelminthiasisefficacymoniezia benedeni |
| spellingShingle | Yu. V. Limova K. M. Sadov S. G. Kanatbaev I. A. Arkhipov ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE Российский паразитологический журнал supramolecular complex phenasalum calves helminthiasis helminthiasis efficacy moniezia benedeni |
| title | ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE |
| title_full | ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE |
| title_fullStr | ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE |
| title_full_unstemmed | ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE |
| title_short | ANTHELMINTIC EFFICACY OF PHENASALUM BASED ON SUPRAMOLECULAR DRUG DELIVERY SYSTEMS (DDS) AT MONIEZIASIS IN CATTLE |
| title_sort | anthelmintic efficacy of phenasalum based on supramolecular drug delivery systems dds at monieziasis in cattle |
| topic | supramolecular complex phenasalum calves helminthiasis helminthiasis efficacy moniezia benedeni |
| url | https://vniigis.elpub.ru/jour/article/view/347 |
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